Original Article

Journal of General Internal Medicine

, 22:215

First online:

Can a Chronic Care Model Collaborative Reduce Heart Disease Risk in Patients with Diabetes?

  • Roberto B. VargasAffiliated withDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLARAND Health Email author 
  • , Carol M. MangioneAffiliated withDivision of General Internal Medicine and Health Services Research, David Geffen School of Medicine at UCLARAND Health
  • , Steven AschAffiliated withRAND HealthDivision of General Internal Medicine, West Los Angeles Veteran’s Administration Hospital, David Geffen School of Medicine at UCLA
  • , Joan KeeseyAffiliated withRAND Health
  • , Mayde RosenAffiliated withRAND Health
  • , Matthias SchonlauAffiliated withRAND Health
  • , Emmett B. KeelerAffiliated withRAND Health

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There is a need to identify effective practical interventions to decrease cardiovascular disease risk in patients with diabetes.


We examine the impact of participation in a collaborative implementing the chronic care model (CCM) on the reduction of cardiovascular disease risk in patients with diabetes.


Controlled pre- and postintervention study.


Persons with diabetes receiving care at 13 health care organizations exposed to the CCM collaborative and controls receiving care in nonexposed sites.

Measurements and Main Results

Ten-year risk of cardiovascular disease; determined using a modified United Kingdom Prospective Diabetes Study risk engine score. A total number of 613 patients from CCM intervention sites and 557 patients from usual care control sites met the inclusion criteria. The baseline mean 10-year risk of cardiovascular disease was 31% for both the intervention group and the control group. Participants in both groups had improved blood pressure, lipid levels, and HbA1c levels during the observation period. Random intercept hierarchical regression models showed that the intervention group had a 2.1% (95% CI −3.7%, −0.5%) greater reduction in predicted risk for future cardiovascular events when compared to the control group. This would result in a reduced risk of one cardiovascular disease event for every 48 patients exposed to the intervention.


Over a 1-year interval, this collaborative intervention using the CCM lowered the cardiovascular disease risk factors of patients with diabetes who were cared for in the participating organization’s settings. Further work could enhance the impact of this promising multifactorial intervention on cardiovascular disease risk reduction.

Key words

chronic care diabetes cardiovascular disease collaborative intervention