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Emerging Trends in the Etiology, Prevention, and Treatment of Gastrointestinal Anastomotic Leakage

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Anastomotic leaks represent one of the most alarming complications following any gastrointestinal anastomosis due to the substantial effects on post-operative morbidity and mortality of the patient with long-lasting effects on the functional and oncologic outcomes. There is a lack of consensus related to the definition of an anastomotic leak, with a variety of options for prevention and management. A number of patient-related and technical risk factors have been found to be associated with the development of an anastomotic leak and have inspired the development of various preventative measures and technologies. The International Multispecialty Anastomotic Leak Global Improvement Exchange group was convened to establish a consensus on the definition of an anastomotic leak as well as to discuss the various diagnostic, preventative, and management measures currently available.

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Authors and Affiliations

  1. Department of Colorectal Surgery, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, FL, 33331, USA

    Sami A. Chadi & Steven D. Wexner

  2. Division of General Surgery, University Health Network, Toronto, ON, Canada

    Sami A. Chadi

  3. Department of Surgery, University of Toronto, Toronto, ON, Canada

    Sami A. Chadi

  4. Section for Surgical Research, Department of Surgery, Medical University of Graz, Graz, Austria

    Abe Fingerhut

  5. First Department of Surgery, Hippokration University Hospital, University of Athens, Athens, Greece

    Abe Fingerhut

  6. Department of Pathology, Cleveland Clinic Florida, Weston, FL, USA

    Mariana Berho

  7. Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Steven R. DeMeester

  8. Department of Surgery, Baylor University Medical Center at Dallas, Dallas, TX, USA

    James W. Fleshman

  9. Department of Surgery, University of Chicago Medicine, Chicago, IL, USA

    Neil H. Hyman

  10. Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, New Orleans, LA, USA

    David A. Margolin

  11. Division of Colorectal Surgery, Mount Sinai Beth Israel, New York, NY, USA

    Joseph E. Martz

  12. Department of Surgery, Colorectal Surgery, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA

    Elisabeth C. McLemore

  13. Division of Thoracic Surgery, Department of Surgery, Johns Hopkins University, Baltimore, MD, USA

    Daniela Molena

  14. Department of Plastic and Reconstructive Surgery, Cleveland Clinic Florida, Weston, FL, USA

    Martin I. Newman

  15. Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Janice F. Rafferty

  16. Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Bashar Safar

  17. Department of Surgery, School of Medicine, Case Western Reserve University, Cleveland, OH, USA

    Anthony J. Senagore

  18. Department of Surgery, Sackler School of Medicine, Sheba Medical Center, Tel Aviv, Israel

    Oded Zmora

Authors
  1. Sami A. Chadi
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  2. Abe Fingerhut
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  3. Mariana Berho
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  6. Neil H. Hyman
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  7. David A. Margolin
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  8. Joseph E. Martz
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  9. Elisabeth C. McLemore
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  10. Daniela Molena
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  11. Martin I. Newman
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  13. Bashar Safar
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  16. Steven D. Wexner
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Corresponding author

Correspondence to Steven D. Wexner.

Ethics declarations

NOVADAQ provided funding for travel and and/or honoraria to the IMAGInE consensus group for the development of this document. The lead author was compensated for the preparation of this mansucript. M Berho is a paid consultant for NOVADAQ; S DeMeester is a paid lecturer for NOVADAQ; D Molena is a paid educational presentation developer for NOVADAQ; A Senagore is a paid lecturer for NOVADAQ; SD Wexner is a paid consultant for NOVADAQ and Karl Storz Endoscopy; O Zmora is a paid lecture and lectures and paid educational lecture developer for NOVADAQ.

Disclosures

NOVADAQ Corporation reviewed the final manuscript but did not have any role in the preparation of the manuscript, selection of the speakers, topics, or content of the symposium, and had no editing privileges. NOVADAQ Corporation did not influence the manuscript.

Authorship Contribution

All authors have made substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; drafting the work or revising it critically for important intellectual content; final approval of the version to be published; and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. NOVADAQ Corporation made no contributions to this manuscript.

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Chadi, S.A., Fingerhut, A., Berho, M. et al. Emerging Trends in the Etiology, Prevention, and Treatment of Gastrointestinal Anastomotic Leakage. J Gastrointest Surg 20, 2035–2051 (2016). https://doi.org/10.1007/s11605-016-3255-3

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