Journal of Gastrointestinal Surgery

, Volume 17, Issue 3, pp 471–481

Race and Correlations Between Lymph Node Number and Survival for Patients with Gastric Cancer

  • Rebecca Nelson
  • Eun Bi Ko
  • Amanda Arrington
  • Wendy Lee
  • Jae Kim
  • Julio Garcia-Aguilar
  • Joseph Kim
Original Article

DOI: 10.1007/s11605-012-2125-x

Cite this article as:
Nelson, R., Ko, E.B., Arrington, A. et al. J Gastrointest Surg (2013) 17: 471. doi:10.1007/s11605-012-2125-x

Abstract

Background

There is ongoing debate whether extended lymphadenectomy improves survival in gastric cancer patients who undergo surgical resection. We previously observed that Korean–American patients had the highest overall survival in Los Angeles County. Our objective was to assess lymph node (LN) number and its impact on survival for Korean–American gastric cancer patients.

Methods

We utilized the National Cancer Institute’s Surveillance, Epidemiology, and End Results registry to identify Korean–Americans with gastric adenocarcinoma treated with curative-intent gastrectomy between 1988 and 2008. We grouped patients according to examined LN number (1–15 and 16+) and compared characteristics. We performed similar analysis for white patients.

Results

Out of 982 Korean–American patients with gastric adenocarcinoma, most patients had 1–15 examined LNs (60 %). When we compared LN groups, we observed higher overall survival in the 1–15 group than the 16+ group (5-year survival, 59 % vs 52 %, respectively; p = 0.04). However, LN number was not prognostic of overall survival on stepwise Cox proportional hazards analysis. In contrast, LN number was prognostic for white patients.

Conclusions

Although examined LN number may impact survival for white patients, outcomes of Korean–American gastric cancer patients were independent of LN number. Our data suggest that survival of Korean–American gastric cancer patients are comparable with outcomes from East Asian hospitals and may be independent of surgical technique.

Keywords

LymphadenectomyGastric cancerSurvivalKorean

Copyright information

© The Society for Surgery of the Alimentary Tract 2012

Authors and Affiliations

  • Rebecca Nelson
    • 1
    • 2
  • Eun Bi Ko
    • 1
    • 2
  • Amanda Arrington
    • 1
    • 2
  • Wendy Lee
    • 1
    • 2
  • Jae Kim
    • 1
    • 2
  • Julio Garcia-Aguilar
    • 1
    • 2
  • Joseph Kim
    • 1
    • 2
  1. 1.Departments of Biostatistics (RN) and Surgery (EBK, AA, WL, JK, JK)City of Hope Comprehensive Cancer CenterDuarteUSA
  2. 2.Department of Surgery (JGA)Memorial Sloan-Kettering Cancer CenterNew YorkUSA