Original Article

Journal of Gastrointestinal Surgery

, Volume 16, Issue 12, pp 2225-2232

Surgical Management Trends for Cholangiocarcinoma in the USA 1998–2009

  • Jamie E. AndersonAffiliated withDepartment of Surgery, University of California, San Diego
  • , Alan W. HemmingAffiliated withDepartment of Surgery, University of California, San Diego
  • , David C. ChangAffiliated withDepartment of Surgery, University of California, San Diego
  • , Mark A. TalaminiAffiliated withDepartment of Surgery, University of California, San Diego
  • , Kristin L. MekeelAffiliated withDepartment of Surgery, University of California, San Diego Email author 

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Abstract

Background

Surgical advancements have improved outcomes for cholangiocarcinoma (CCA) patients, but this expertise is not uniformly available. This research examines CCA surgical treatment patterns.

Methods

A retrospective analysis of the U.S. Nationwide Inpatient Sample from 1998–2009 identified CCA patients at high-volume (HV) versus low-volume (LV) hospitals, and teaching versus nonteaching hospitals. We performed multinomial and multivariate logistic regressions to compare differences of surgical treatment between HV vs. LV hospitals, and teaching vs. nonteaching hospitals. Liver resection (LR), pancreaticoduodenectomy, bile duct (BD) resection, and combined liver/BD resection were considered more aggressive therapy than BD stent or bypass.

Results

A total of 32,561 patients with CCA were identified. The proportion receiving surgery declined from 36 to 30 %. There was no increase in the proportion of LRs or combined liver/BD resection. Patients at HV or teaching hospitals were more likely to receive surgical treatment [odds ratio (OR), 1.3, p < 0.001; OR, 1.4, p < 0.001].

Discussion

Despite increasing evidence that surgical resection increases survival, the number of patients receiving surgery has decreased. Although combined liver/BD resection has been advocated as standard management for proximal CCA, the practice has not increased. All patients with CCA should be considered for assessment at a HV teaching hospital.

Keywords

Cholangiocarcinoma Outcomes research Hepatectomy Liver transplantation