, Volume 16, Issue 9, pp 1641-1644
Date: 29 Jun 2012

Overview of Personalized Medicine in GI Cancers

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Abstract

Cancer biomarkers may be used for prevention (identification of patients at high risk for cancer), estimating prognosis and/or repsonse to conventional chemotherapies, or guide the use of specific targeted therapies. This overview provides examples in each category for gastrointestinal cancers and reviews current concepts in personalized medicine.

This paper was originally presented as part of the SSAT State-of-the-Art Conference, Personalized Medicine in Gastrointestinal Cancer: Potential Applications in Clinical Practice, at the SSAT 52nd Annual Meeting, May 2011, in Chicago, Illinois. The other articles presented in the conference were Riall TS, Introduction: Personalized Medicine in Gastrointestinal Cancer; Carethers JM, Proteomics, Genomics and Molecular Biology in the Personalized Treatment of Colorectal Cancer; Iacobuzio-Donahue CA, Personalized Medicine in Pancreatic Cancer: Prognosis and Potential Implications for Therapy; and DeMatteo RP, Personalized Therapy: Prognostic Factors in Gastrointestinal Stromal Tumor (GIST).