Find out how to access preview-only content
Personalized Medicine in Pancreatic Cancer: Prognosis and Potential Implications for Therapy
- Christine A. Iacobuzio-Donahue
- … show all 1 hide
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
This paper was originally presented as part of the SSAT State-of-the-Art Conference, Personalized Medicine in Gastrointestinal Cancer: Potential Applications in Clinical Practice, at the SSAT 52nd Annual Meeting, May 2011, in Chicago, IL, USA. The other articles presented in the conference were Riall TS, Introduction: Personalized Medicine in Gastrointestinal Cancer; Chao C, Overview of Personalized Medicine in GI Cancers; Carethers JM, Proteomics, Genomics and Molecular Biology in the Personalized Treatment of Colorectal Cancer; and DeMatteo RP, Personalized Therapy: Prognostic Factors in Gastrointestinal Stromal Tumor (GIST).
- Jemal, A., et al. Cancer statistics, 2010. CA: A Cancer Journal for Clinicians 2010; 60(5):277–300. CrossRef
- Stathis, A., et al. Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev Clin Oncol 2010; 7(3):163–72. CrossRef
- Yachida, S., et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010; 467(7319):1114–7. CrossRef
- Goggins, M. Identifying molecular markers for the early detection of pancreatic neoplasia. Seminars in oncology 2007; 34(4):303–10. CrossRef
- Embuscado, E.E., et al. Immortalizing the complexity of cancer metastasis: Genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. Cancer Biology & Therapy 2005; 4(5):548–54. CrossRef
- Iacobuzio-Donahue, C.A., et al. Dpc4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. J Clin Oncol 2009; 27(11):1806–13. CrossRef
- Wilentz, R.E., et al. Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas: a new marker of dpc4 inactivation. The American Journal of Pathology 2000; 156(1):37–43. CrossRef
- Blackford, A., et al. Smad4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res 2009; 15(14):4674–9. CrossRef
- Massague, J. Tgfbeta in cancer. Cell 2008; 134(2):215–30. CrossRef
- Dai, J.L., et al. G1 cell cycle arrest and apoptosis induction by nuclear smad4/dpc4: phenotypes reversed by a tumorigenic mutation. Proceedings of the National Academy of Sciences of the United States of America 1999; 96(4):1427–32. CrossRef
- Dai, J.L., et al. Transforming growth factor-beta responsiveness in dpc4/smad4-null cancer cells. Molecular Carcinogenesis 1999; 26(1):37–43. CrossRef
- Yue, J., et al. Activation of the mitogen-activated protein kinase pathway by transforming growth factor-beta. Methods in Molecular Biology (Clifton, NJ) 2000; 142:125–31.
- Yu, L., et al. Tgf-beta receptor-activated p38 map kinase mediates smad-independent tgf-beta responses. The EMBO Journal 2002; 21(14):3749–59. CrossRef
- Derynck, R., et al. Smad-dependent and smad-independent pathways in tgf-beta family signalling. Nature 2003; 425(6958):577–84. CrossRef
- Moustakas, A., et al. Non-smad tgf-beta signals. Journal of Cell Science 2005; 118(Pt 16):3573–84. CrossRef
- Bakin, A.V., et al. Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. The Journal of Biological Chemistry 2000; 275(47):36803–10. CrossRef
- Gordon, K.J., et al. Loss of type iii transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression. Carcinogenesis 2008; 29(2):252–62. CrossRef
- Jungert, K., et al. Sp1 is required for transforming growth factor-beta-induced mesenchymal transition and migration in pancreatic cancer cells. Cancer Res 2007; 67(4):1563–70. CrossRef
- Kern, S.E., et al. The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting. The Journal of Pathology; 223(2):295–306.
- Ko, A.H., et al. Radiation therapy in operable and locally advanced pancreatic cancer. J Natl Compr Canc Netw 2010; 8(9):1022–31.
- Gutt, R., et al. The role of radiotherapy in locally advanced pancreatic carcinoma. Nat Rev Gastroenterol Hepatol 2010; 7(8):437–47. CrossRef
- Personalized Medicine in Pancreatic Cancer: Prognosis and Potential Implications for Therapy
Journal of Gastrointestinal Surgery
Volume 16, Issue 9 , pp 1651-1652
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Christine A. Iacobuzio-Donahue (1) (2)
- Author Affiliations
- 1. Departments of Pathology, Oncology and Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, 21231, USA
- 2. Department of Pathology, GI/Liver Division, 1550 Orleans Street, CRB2 Rm 343, Baltimore, MD, 21231, USA