Journal of Gastrointestinal Surgery

, Volume 16, Issue 2, pp 435–446

Contemporary Management of Nonfunctioning Pancreatic Neuroendocrine Tumors

Review Article

DOI: 10.1007/s11605-011-1693-5

Cite this article as:
Minter, R.M. & Simeone, D.M. J Gastrointest Surg (2012) 16: 435. doi:10.1007/s11605-011-1693-5



This article reviews the current literature and recommendations pertaining to the management of nonfunctioning pancreatic neuroendocrine tumors.


In recent years the detection of nonfunctioning pancreatic neuroendocrine tumors has increased coincident with the increased use of cross-sectional imaging and is now thought to represent 2–10% of all pancreatic tumors. Improved understanding of the biology and behavior of these heterogeneous tumors is needed to guide therapy. The present review discusses diagnostics, therapeutics including emerging molecular analytics, and surveillance recommendations.


PancreasPancreaticNF-PNETNeuroendocrine tumorNonfunctioning

Copyright information

© The Society for Surgery of the Alimentary Tract 2011

Authors and Affiliations

  1. 1.Department of SurgeryUniversity of MichiganAnn ArborUSA