Journal of Gastrointestinal Surgery

, 15:1783

Predictable Factors for Lymph Node Metastasis in Early Gastric Cancer—Analysis of Single Institutional Experience

  • Man Sup Lim
  • Hae-Wan Lee
  • Hyoungjune Im
  • Byung Seup Kim
  • Mi Yeol Lee
  • Jang Yong Jeon
  • Dae Hyun Yang
  • Bong Hwa Lee
Original Article

DOI: 10.1007/s11605-011-1624-5

Cite this article as:
Lim, M.S., Lee, H., Im, H. et al. J Gastrointest Surg (2011) 15: 1783. doi:10.1007/s11605-011-1624-5

Abstract

Introduction

Prediction of lymph node metastasis in early gastric cancer (EGC) is very important to decide treatment strategies preoperatively. The aim of this study was to evaluate factors that predict the presence of lymph node metastasis and to indentify the differences between mucosal and submucosal gastric cancers.

Methods

A total of 376 patients with EGC who underwent gastrectomy from March 1999 through December 2007 were retrospectively identified. The clinopathological factors and biological markers (p53, Ki67) were analyzed.

Results

The rate of lymph node metastasis was 9.6% (mucosal cancer 2.8%, submucosal cancer 18.4%). Tumor size, depth of invasion, macroscopic type, and lymphovascular invasion were related to lymph node metastasis in EGC. When the carcinomas were confined to the mucosal layer, tumor size and lymphovascular invasion showed significant correlation with lymph node metastasis. On the other side, macroscopic type and lymphovascular invasion were association with lymph node metastasis in submucosal carcinoma.

Conclusion

The risk factors for lymph node metastasis in EGC are quite different depending on depth of tumor invasion. To predict lymph node metastasis in EGC, it is recommended that distinct assessment according to individual situation should be clearly established.

Keywords

Early gastric cancerLymph node metastasisp53KI67

Copyright information

© The Society for Surgery of the Alimentary Tract 2011

Authors and Affiliations

  • Man Sup Lim
    • 1
  • Hae-Wan Lee
    • 2
  • Hyoungjune Im
    • 3
  • Byung Seup Kim
    • 1
  • Mi Yeol Lee
    • 1
  • Jang Yong Jeon
    • 1
  • Dae Hyun Yang
    • 4
  • Bong Hwa Lee
    • 1
  1. 1.Department of SurgeryHallym University Sacred Heart HospitalAnyangSouth Korea
  2. 2.Department of SurgeryHallym University Hangang Sacred Heart HospitalSeoulSouth Korea
  3. 3.Department of Occupation and Environmental MedicineHallym University Sacred Heart HospitalAnyangSouth Korea
  4. 4.Department of SurgeryHallym University Kangnam Sacred Heart HospitalSeoulSouth Korea