Journal of Gastrointestinal Surgery

, Volume 14, Issue 11, pp 1796–1803

Surgical Resection and Multidisciplinary Care for Primary and Metastatic Pancreatic Islet Cell Carcinomas

Authors

  • Shaun McKenzie
    • Department of Oncologic SurgeryCity of Hope Comprehensive Cancer Center
  • Wendy Lee
    • Department of Oncologic SurgeryCity of Hope Comprehensive Cancer Center
  • Avo Artinyan
    • Michael E. Debakey Department of SurgeryBaylor College of Medicine
  • Brian Mailey
    • Department of Oncologic SurgeryCity of Hope Comprehensive Cancer Center
  • Alessio Pigazzi
    • Department of Oncologic SurgeryCity of Hope Comprehensive Cancer Center
  • Joshua Ellenhorn
    • Department of Oncologic SurgeryCity of Hope Comprehensive Cancer Center
    • Department of Oncologic SurgeryCity of Hope Comprehensive Cancer Center
2010 SSAT Poster Presentation

DOI: 10.1007/s11605-010-1225-8

Cite this article as:
McKenzie, S., Lee, W., Artinyan, A. et al. J Gastrointest Surg (2010) 14: 1796. doi:10.1007/s11605-010-1225-8

Abstract

Introduction

The role of multidisciplinary management of islet cell cancers (ICC) has not been fully investigated in a population-based setting.

Methods

The Los Angeles County Cancer Surveillance Program was assessed for patients with ICC between the years 1982 to 2006. Patients were stratified by treatment received and clinicopathologic characteristics and survival were compared.

Results

We identified 236 patients with ICC; 86 patients underwent curative-intent surgery with median survival for local, regional, and distant disease of 17.3, 12.2, and 4.0 years, respectively. In comparison, 102 patients underwent medical management alone; survival was significantly shorter when compared to the surgical cohort for local, regional, and distant disease (p < 0.05). To determine whether adjuvant chemotherapy was associated with improved survival, we compared patients who underwent surgery alone compared to patients who underwent surgery followed by adjuvant chemotherapy. Although patients with metastatic disease had 3-year longer survival with adjuvant chemotherapy, these improvements in survival were not statistically significant.

Conclusion

Surgical resection was associated with improved survival compared to medical management for any extent of disease in patients with ICC. Furthermore, adjuvant chemotherapy was not associated with survival but does warrant further examination in patients with metastatic disease.

Keywords

Islet cell carcinomaPancreatic resectionChemotherapyMultimodality therapy

Copyright information

© The Society for Surgery of the Alimentary Tract 2010