Original Article

Journal of Gastrointestinal Surgery

, Volume 14, Issue 5, pp 880-883

Management and Outcome of Gastrointestinal Stromal Tumors of the Duodenum

  • Jun Chul ChungAffiliated withDepartment of Surgery, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital Email author 
  • , Chong Woo ChuAffiliated withDepartment of Surgery, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital
  • , Gyu Seok ChoAffiliated withDepartment of Surgery, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital
  • , Eung Jin ShinAffiliated withDepartment of Surgery, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital
  • , Chul Wan LimAffiliated withDepartment of Surgery, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital
  • , Hyung Chul KimAffiliated withDepartment of Surgery, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital
  • , Ok Pyung SongAffiliated withDepartment of Surgery, Soonchunhyang University College of Medicine, Soonchunhyang University Bucheon Hospital

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

Background

Duodenal gastrointestinal stromal tumors (GISTs) are uncommon and relatively small subset of GISTs whose optimal surgical procedure has not been well defined. We conducted this study to present the surgical experience in our institution and to analyze the postoperative outcome of duodenal GISTs.

Methods

A retrospective clinicopathologic analysis was performed for nine duodenal GIST patients who underwent surgery from May 2001 to April 2009. The median follow-up period was 22 months (range: 13–61 months).

Results

A total of nine patients (six males/three females) with a median age of 52 years (range: 45-73 years) were treated. The most common presentation was abdominal pain (45%), and the second portion of duodenum (45%) was most common dominant site. All of the patients underwent limited resection: there were seven wedge resections with primary closures (five open/two laparoscopic) and two segmental resections with end-to-end duodenojejunostomies. The median tumor size was 3.5 cm (range: 1.9-5.5 cm), and the mitotic count was less than fivemitoses/50 high power fields (HPF) in all cases. None patients had neoadjuvant or adjuvant therapy. All of the patients were alive and disease-free.

Conclusion

We obtained excellent disease-free survival following limited resection with clear margins. Limited resection should be considered a treatment option for duodenal GIST.

Keywords

Gastrointestinal stromal tumor Duodenum Surgery