Solitary Necrotic Nodule of the Liver: Always Benign?
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Solitary necrotic nodule of the liver (SNNL) is a rare lesion and accepted as a benign entity. The aim of this study is to investigate the possible causes for the development of solitary necrotic nodules.
Twenty-two retrospective solitary necrotic nodule specimens were examined to evaluate histologic features. The clinical records of these patients were reviewed, and clinical data were obtained for all patients.
Histologically, 17 of the 22 nodules were necrotic with surrounding fibrosis, and the remaining five nodules were completely fibrotic. Four of the 22 cases were found to have specific lesions within the nodules which may put light on the pathogenesis. Foci of metastatic carcinoma were identified in two of these four cases, and cuticle fragments of the hydatid cyst were identified in the other two cases. Clinical data showed that half of the cases with solitary necrotic nodule have an associated malignancy mainly involving the gastrointestinal system.
SNNL is not always benign. The possible causes of this lesion include parasites and metastatic tumors. It is important to identify the minute foci of metastatic carcinoma for the appropriate management of this lesion.
- Shepherd NA, Lee G. Solitary necrotic nodule of the liver simulating hepatic metastasis. J Clin Pathol 1983;36:1181–1183. CrossRef
- Zhou YM, Li B, Xu F, Wang B, Li DQ, Liu P, Yang JM. Clinical features of solitary necrotic nodule of the liver. Hepatobiliary Pancreat Dis Int 2008;7:485–489.
- Shepherd NA. Solitary necrotic nodule. J Clin Pathol 1990;43:348–349. CrossRef
- Patti R, Cabibi D, Sparacello M, Di Vita G, Montalto G. Solitary necrotic nodule of the liver: different pathological findings express a different histogenesis. Case Rep Gastroenterol 2008;2:149–154 CrossRef
- Sundaresan M, Lyons B, Akosa AB. ‘Solitary’ necrotic nodules of the liver: an aetiology reaffirmed. Gut 1991;32:1378–1380. CrossRef
- Delis SG, Kelgiorgi DA, Sofianidis AA, Triantopoulou CC, Papailiou IA, Dervenis CG. Solitary necrotic nodule of the liver mimicking hepatocellular carcinoma: a case report. Cases J 2009;2:85. CrossRef
- Tsui WM, Yuen RW, Chow LT, Tse CC. Solitary necrotic nodule of the liver: parasitic origin? J Clin Pathol 1992;45:975–978. CrossRef
- Berry CL. Solitary “necrotic nodule” of the liver: a probable pathogenesis. J Clin Pathol 1985;38:1278–1280. CrossRef
- Clouston AD, Walker NI, Prociv P. Parasitic origin of a solitary necrotic nodule of the liver. J Clin Pathol 1993;46:578. CrossRef
- Koea J, Smith D. Solitary necrotic nodule revisited. ANZ J Surg 2008;78:109–111. CrossRef
- De Luca M, Luigi B, Formisano C, Formato A, De Werra C, Cappuccio M, Loffredo A, Forestieri P. Solitary necrotic nodule of the liver misinterpreted as malignant lesion: considerations on two cases. J Surg Oncol 2000;74:219–222. CrossRef
- Kondi-Pafiti AI, Grapsa DS, Kairi-Vasilatou ED, Voros DK, Smyrniotis VE. “Solitary” necrotic nodule of the liver: an enigmatic entity mimicking malignancy. Int J Gastrointest Cancer 2006;37:74–78. CrossRef
- Iwase K, Higaki J, Yoon HE, Mikata S, Miyazaki M, Torikai K, Shirai Y, Awai K, Imakita M, Kamiike W. Solitary necrotic nodule of the liver. J Hepatobiliary Pancreat Surg 2002;9:120–124. CrossRef
- Colagrande S, Politi LS, Messerini L, Mascalchi M, Villari N. Solitary necrotic nodule of the liver: imaging and correlation with pathologic features. Abdom Imaging 2003;28:41–44. CrossRef
- Yoon KH, Yun KJ, Lee JM, Kim CG. Solitary necrotic nodules of the liver mimicking hepatic metastasis: report of two cases. Korean J Radiol 2000;1:165–168. CrossRef
- Solitary Necrotic Nodule of the Liver: Always Benign?
Journal of Gastrointestinal Surgery
Volume 14, Issue 3 , pp 536-540
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