Journal of Gastrointestinal Surgery

, Volume 13, Issue 4, pp 695–701

Hepatectomy for Hepatocellular Carcinoma in Elderly Patients Aged 75 Years or More

  • Koichi Oishi
  • Toshiyuki Itamoto
  • Tsuyoshi Kobayashi
  • Akihiko Oshita
  • Hironobu Amano
  • Hideki Ohdan
  • Hirotaka Tashiro
  • Toshimasa Asahara
original article

DOI: 10.1007/s11605-008-0758-6

Cite this article as:
Oishi, K., Itamoto, T., Kobayashi, T. et al. J Gastrointest Surg (2009) 13: 695. doi:10.1007/s11605-008-0758-6
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Abstract

Background

The aim of this study was to clarify the characteristics of elderly hepatocellular carcinoma (HCC) patients aged 75 years or more who underwent hepatectomy and to clarify whether elderly patients with HCC benefit from hepatectomy.

Methods

Between January 1990 and December 2006, 570 patients underwent curative hepatectomy for HCC. Elderly patients were defined as those aged 75 years or more. Clinicopathological data and outcomes after hepatectomy for 64 elderly and 502 younger patients were prospectively collected and compared.

Results

The proportion of elderly patients with chronic viral infection was less than that of younger patients (p < 0.001). Cirrhotic patients in the elderly group were less than those in the younger group (p = 0.03). The elderly patients had better liver function than did the younger patients (p = 0.007) but had more advanced HCC with microscopic vascular invasion than did the younger patients (p = 0.04). There was no operative mortality in the elderly patients and there was no significant difference in postoperative complication rates and long-term survival after hepatectomy between the two groups.

Conclusions

Hepatectomy for elderly patients with resectable HCC is safe and feasible. Selected elderly patients with HCC might benefit from hepatectomy.

Keywords

Hepatocellular carcinomaHepatectomyElderly

Copyright information

© The Society for Surgery of the Alimentary Tract 2008

Authors and Affiliations

  • Koichi Oishi
    • 1
    • 2
  • Toshiyuki Itamoto
    • 1
  • Tsuyoshi Kobayashi
    • 1
  • Akihiko Oshita
    • 1
  • Hironobu Amano
    • 1
  • Hideki Ohdan
    • 1
  • Hirotaka Tashiro
    • 1
  • Toshimasa Asahara
    • 1
  1. 1.Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical SciencesHiroshima UniversityHiroshimaJapan
  2. 2.Department of SurgeryFuchu Kita City HospitalFuchuJapan