Liver Regeneration and Tumor Stimulation—A Review of Cytokine and Angiogenic Factors

  • Christopher Christophi
  • Nadia Harun
  • Theodora Fifis
Article

DOI: 10.1007/s11605-007-0459-6

Cite this article as:
Christophi, C., Harun, N. & Fifis, T. J Gastrointest Surg (2008) 12: 966. doi:10.1007/s11605-007-0459-6

Abstract

Liver resection for metastatic (colorectal carcinoma) tumors is often followed by a significant incidence of tumor recurrence. Cellular and molecular changes resulting from hepatectomy and the subsequent liver regeneration process may influence the kinetics of tumor growth and contribute to recurrence. Clinical and experimental evidence suggests that factors involved in liver regeneration may also stimulate the growth of occult tumors and the reactivation of dormant micrometastases. An understanding of the underlying changes may enable alternative strategies to minimize tumor recurrence and improve patient survival after hepatectomy.

Keywords

Colorectal carcinomaLiver resectionLiver regenerationCytokinesAngiogenesisGrowth factorsTumor recurrence

Copyright information

© The Society for Surgery of the Alimentary Tract 2007

Authors and Affiliations

  • Christopher Christophi
    • 1
  • Nadia Harun
    • 1
  • Theodora Fifis
    • 1
  1. 1.Department of SurgeryUniversity of MelbourneMelbourneAustralia