Journal of Gastrointestinal Surgery

, Volume 12, Issue 3, pp 592–600

A Prospective, Double-Blind, Multicenter, Randomized Trial Comparing Ertapenem 3 Vs ≥5 Days in Community-Acquired Intraabdominal Infection

  • Antonio Basoli
  • Piero Chirletti
  • Ercole Cirino
  • Nicola G. D’Ovidio
  • Giovanni Battista Doglietto
  • Domenico Giglio
  • Stefano M. Giulini
  • Alberto Malizia
  • Mario Taffurelli
  • Jelena Petrovic
  • Maurizio Ecari
  • Italian Study Group
Article

DOI: 10.1007/s11605-007-0277-x

Cite this article as:
Basoli, A., Chirletti, P., Cirino, E. et al. J Gastrointest Surg (2008) 12: 592. doi:10.1007/s11605-007-0277-x

Abstract

Severe secondary peritonitis is diagnosed in only 20–30% of all patients, but studies to date have persisted in using a standard fixed duration of antibiotic therapy. This prospective, double-blind, multicenter, randomized clinical study compared the clinical and bacteriological efficacy and tolerability of ertapenem (1 g/day) 3 days (group I) vs ≥5 days (group II) in 111 patients with localized peritonitis (appendicitis vs non-appendicitis) of mild to moderate severity, requiring surgical intervention. In evaluable patients, the clinical response as primary efficacy outcome were assessed at the test-of-cure 2  and 4 weeks after discontinuation of antibacterial therapy. Ninety patients were evaluable. In groups I and II, 92.9 and 89.6% of patients were cured, respectively; 95.3% in group I and 93.7% in group II showed eradication. These differences were not statistically significant. The most frequent bacteria recovered were Escherichia coli and Bacteroides fragilis. A wound infection developed in seven patients (7.7%) and an intraabdominal infection in one patient (1.1%). There was a low frequency of drug-related clinical or laboratory adverse effects in both groups. Our study demonstrated that, in patients with localized community-acquired intraabdominal infection, a 3-day course of ertapenem had the same clinical and bacteriological efficacy as a standard duration.

Keywords

Peritonitis Ertapenem Localized intraabdominal infection Surgical and antibiotic therapy 

Copyright information

© The Society for Surgery of the Alimentary Tract 2007

Authors and Affiliations

  • Antonio Basoli
    • 1
  • Piero Chirletti
    • 2
  • Ercole Cirino
    • 3
  • Nicola G. D’Ovidio
    • 4
  • Giovanni Battista Doglietto
    • 5
  • Domenico Giglio
    • 6
  • Stefano M. Giulini
    • 7
  • Alberto Malizia
    • 2
  • Mario Taffurelli
    • 8
  • Jelena Petrovic
    • 9
  • Maurizio Ecari
    • 9
  • Italian Study Group
  1. 1.Department “Paride Stefanini”University “La Sapienza”RomeItaly
  2. 2.Department of Emergency SurgeryUniversity “ La Sapienza”RomeItaly
  3. 3.Department of Emergency SurgeryUniversity of CataniaCataniaItaly
  4. 4.Department of Emergency SurgeryUniversity of SassariSassariItaly
  5. 5.Department of SurgeryCatholic University of RomeRomeItaly
  6. 6.Department of SurgeryS. Giovanni Bosco HospitalNaplesItaly
  7. 7.Department of SurgeryUniversity of BresciaBresciaItaly
  8. 8.Department of Emergency SurgeryUniversity of BolognaBolognaItaly
  9. 9.Merck Sharp and DohmeRomeItaly