Japanese Journal of Radiology

, 29:570

Selective intraarterial chemoradiation therapy for oropharyngeal carcinoma with high-dose cisplatin

Authors

  • Ryota Nishio
    • Department of RadiologyTokyo Medical University
    • Department of RadiologyTokyo Medical University
  • Hiroyuki Ito
    • Department of OtolaryngologyTokyo Medical University
  • Tomoyuki Yoshida
    • Department of OtolaryngologyTokyo Medical University
  • Koichi Kitamura
    • Department of OtolaryngologyTokyo Medical University
  • Akira Shimizu
    • Department of OtolaryngologyTokyo Medical University
  • Naoto Kanesaka
    • Department of RadiologyTokyo Medical University
  • Ryuji Mikami
    • Department of RadiologyTokyo Medical University
  • Daisuke Hasegawa
    • Department of RadiologyTokyo Medical University
  • Mamoru Suzuki
    • Department of OtolaryngologyTokyo Medical University
  • Koichi Tokuuye
    • Department of RadiologyTokyo Medical University
Original Article

DOI: 10.1007/s11604-011-0599-1

Cite this article as:
Nishio, R., Saito, K., Ito, H. et al. Jpn J Radiol (2011) 29: 570. doi:10.1007/s11604-011-0599-1

Abstract

Purpose

Cisplatin has shown a high tumor response rate among head and neck carcinomas, and the tumor response is related to the cisplatin dosage. The purpose of this study was to evaluate the efficacy and toxicity of selective intraarterial chemoradiation therapy for oropharyngeal carcinomas with high-dose cisplatin.

Materials and methods

This retrospective study consisted of 21 patients with oropharyngeal carcinoma, stages II-IVB, in whom intraarterial chemoradiation therapy was performed between 2000 and 2008. All patients were given two courses of selective intraarterial infusions of cisplatin (300 mg/m2), systemic chemotherapy with 5-fluorouracil, and simultaneous radiation therapy (58–61 Gy/30 fractions), with a 1-week rest period.

Results

The 2-year overall survival rate of the 15 patients who completed the therapeutic regimen was 71.3%. The 2-year locoregional control rate and disease-free survival rate were 95.0% and 67.7%, respectively.

Conclusion

Selective intraarterial high-dose cisplatin chemotherapy with concomitant radiation therapy shows results similar to those of original methods in terms of survival and locoregional control with a reduction in the number of procedure times.

Key words

Oropharyngeal carcinomaIntraarterial chemotherapyCisplatinInterventional radiology

Copyright information

© Japan Radiological Society 2011