Japanese Journal of Radiology

, Volume 28, Issue 6, pp 446–452

Preliminary study of positron emission tomography/computed tomography and plasma osteopontin levels in patients with asbestos-related pleural disease

  • Seiji Kurata
  • Masatoshi Ishibashi
  • Koichi Azuma
  • Hayato Kaida
  • Shinzo Takamori
  • Kiminori Fujimoto
  • Maiko Kobayashi
  • Yasumitsu Hirose
  • Hisamichi Aizawa
  • Naofumi Hayabuchi
Original Article

DOI: 10.1007/s11604-010-0449-6

Cite this article as:
Kurata, S., Ishibashi, M., Azuma, K. et al. Jpn J Radiol (2010) 28: 446. doi:10.1007/s11604-010-0449-6

Abstract

Purpose

The aim of this study was to compare the results of semiquantitative analysis by18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) with plasma osteopontin levels in the same asbestos-related pleural disease population.

Materials and methods

A total of 17 patients with asbestos-related pleural disease were prospectively recruited. They underwent PET/CT, and plasma osteopontin levels were measured. The maximum standardized uptake value (SUVmax) was determined from the most active pleural lesion in each patient.

Results

Malignant pleural mesothelioma (MPM) was histologically proven in 6 patients, and 11 patients had proven benign asbestos-related pleural diseases (7 pleural plaques, 4 asbestos pleurisy). Significant differences in SUVmax were found between patients with MPM and those with asbestos pleurisy (P = 0.031) and between patients with MPM and those with pleural plaques (P = 0.012). A significant difference was found in the plasma osteopontin levels between patients with asbestos pleurisy and patients with pleural plaques (Bonferroni correction, P = 0.024). The SUVmax in patients with benign asbestos-related diseases was statistically positively correlated with plasma osteopontin in the same group (Spearman’s r = 0.75, P < 0.05).

Conclusion

PET/CT might be more helpful than plasma osteopontin for distinguishing benign asbestos-related pleural diseases from MPM, and the SUVmax in benign asbestos-related pleural diseases may reflect changes in pleural inflammation.

Key words

PET/CT Asbestos Osteopontin Malignant mesothelioma 

Copyright information

© Japan Radiological Society 2010

Authors and Affiliations

  • Seiji Kurata
    • 1
  • Masatoshi Ishibashi
    • 1
  • Koichi Azuma
    • 2
  • Hayato Kaida
    • 1
  • Shinzo Takamori
    • 3
  • Kiminori Fujimoto
    • 4
  • Maiko Kobayashi
    • 1
  • Yasumitsu Hirose
    • 1
  • Hisamichi Aizawa
    • 2
  • Naofumi Hayabuchi
    • 4
  1. 1.Division of Nuclear Medicine and PET Center, Department of RadiologyKurume University School of MedicineKurumeJapan
  2. 2.Division of Respiratory, Neurology, and Rheumatology, Department of MedicineKurume University School of MedicineKurumeJapan
  3. 3.Department of SurgeryKurume University School of MedicineKurumeJapan
  4. 4.Department of RadiologyKurume University School of Medicine and Center for Diagnostic Imaging, Kurume University HospitalKurumeJapan

Personalised recommendations