Journal of Huazhong University of Science and Technology [Medical Sciences]

, Volume 32, Issue 6, pp 823–828

Role of neuropeptide Y and peroxisome proliferator-activated receptor γ coactivator-1α in stress cardiomyopathy

  • Sunnassee Ananda阿兰达
  • Yunyun Wang王云云
  • Shaohua Zhu朱少华
  • Rongshuai Wang王荣帅
  • Xiaowei Zhou周小伟
  • Luo Zhuo卓 荦
  • Tingyi Sun孙婷怡
  • Liang Ren任 亮
  • Qian Liu刘 茜
  • Hongmei Dong董红梅
  • Yan Liu刘 艳
  • Liang Liu刘 良
Article

DOI: 10.1007/s11596-012-1041-3

Cite this article as:
Ananda, S., Wang, Y., Zhu, S. et al. J. Huazhong Univ. Sci. Technol. [Med. Sci.] (2012) 32: 823. doi:10.1007/s11596-012-1041-3
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Summary

Death following situations of intense emotional stress has been linked to the cardiac pathology described as stress cardiomyopathy, whose pathomechanism is still not clear. In this study, we sought to determine, via an animal model, whether the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC-1α) and the amino peptide neuropeptide Y (NPY) play a role in the pathogenesis of this cardiac entity. Male Sprague-Dawley rats in the experimental group were subjected to immobilization in a plexy glass box for 1 h, which was followed by low voltage electric foot shock for about 1 h at 10 s intervals in a cage fitted with metallic rods. After 25 days the rats were sacrificed and sections of their hearts were processed. Hematoxylin-eosin staining of cardiac tissues revealed the characteristic cardiac lesions of stress cardiomyopathy such as contraction band necrosis, inflammatory cell infiltration and fibrosis. The semi-quantitative RT-PCR analysis for PGC-1α mRNA expression showed significant overexpression of PGC1-α in the stress-subjected rats (P<0.05). Fluorescence immunohistochemistry revealed a higher production of NPY in the stress-subjected rats as compared to the control rats (P=0.0027). Thus, we are led to conclude that following periods of intense stress, an increased expression of PGC1-α in the heart and an overflow of NPY may lead to stress cardiomyopathy and even death in susceptible victims. Moreover, these markers can be used to identify stress cardiomyopathy as the cause of sudden death in specific cases.

Key words

stress cardiomyopathyperoxisome proliferator-activated receptor γ coactivator-1alphaneuropeptide Ysudden deathforensic pathology

Copyright information

© Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Sunnassee Ananda阿兰达
    • 1
  • Yunyun Wang王云云
    • 1
  • Shaohua Zhu朱少华
    • 1
  • Rongshuai Wang王荣帅
    • 1
  • Xiaowei Zhou周小伟
    • 1
  • Luo Zhuo卓 荦
    • 1
  • Tingyi Sun孙婷怡
    • 1
  • Liang Ren任 亮
    • 1
  • Qian Liu刘 茜
    • 1
  • Hongmei Dong董红梅
    • 1
  • Yan Liu刘 艳
    • 1
  • Liang Liu刘 良
    • 1
  1. 1.Department of Forensic Medicine, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina