Journal of Huazhong University of Science and Technology [Medical Sciences]

, 31:515

Different optical properties between human hepatocellular carcinoma tissues and non-tumorous hepatic tissues In Vitro

Authors

  • Yuan Yu于 愿
    • Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and Technology
  • Chaowen Xiao肖朝文
    • Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and Technology
  • Kun Chen陈 堃
    • Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and Technology
  • Jianwei Zheng郑建伟
    • Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and Technology
  • Jun Zhang张 俊
    • Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and Technology
  • Xinyang Zhao赵新阳
    • Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and Technology
    • Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and Technology
Article

DOI: 10.1007/s11596-011-0482-4

Cite this article as:
Yu, Y., Xiao, C., Chen, K. et al. J. Huazhong Univ. Sci. Technol. [Med. Sci.] (2011) 31: 515. doi:10.1007/s11596-011-0482-4

Summary

There has been an ongoing search for clinically acceptable methods for the accurate, efficient and simple diagnosis and prognosis of hepatocellular carcinoma (HCC). Optical spectroscopy is a technique with potential clinical applications to diagnose cancer diseases. The purpose of this study was to obtain the optical properties of HCC tissues and non-tumorous hepatic tissues and identify the difference between them. A total of 55 tissue samples (HCC tissue, n=38; non-tumorous hepatic tissue, n=17) were surgically resected from patients with HCC. The optical parameters were measured in 10-nm steps using single-integrating-sphere system in the wavelength range of 400 to 1800 nm. It was found that the optical properties and their differences varied with the wavelength for the HCC tissue and the non-tumorous hepatic tissue in the entire wavelength range of research. The absorption coefficient of the HCC tissue (1.48±0.99, 1.46±0.88, 0.86±0.61, 2.15±0.53, 0.54±0.10, 0.79±0.15 mm−1) was significantly lower than that of the non-tumorous hepatic tissue (2.79±1.73, 3.13±1.47, 3.06±2.79, 2.57±0.55, 0.62±0.10, 0.93±0.16 mm−1) at wavelengths of 400, 410, 450, 1450, 1660 and 1800 nm, respectively (P<0.05). The reduced scattering coefficient of HCC tissue (5.28±1.70, 4.91±1.54, 1.26±0.35 mm−1) and non-tumorous hepatic tissue (8.14±3.70, 9.27±3.08, 2.55±0.57 mm−1) was significantly different at 460, 500 and 1800 nm respectively (P<0.05). These results show different pathologic liver tissues have different optical properties. It provides a better understanding of the relationship between optical parameters and physiological characteristics in human liver tissues. And it would be very useful for developing a non-invasive, real-time, simple and efficient way for medical management of HCC in the future.

Key words

carcinoma hepatocellular optical properties integrating sphere

Copyright information

© Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2011