Journal of Huazhong University of Science and Technology [Medical Sciences]

, Volume 29, Issue 1, pp 77–79

Costimulatory molecule B7-H1 on the immune escape of bladder cancer and its clinical significance

  • Yonghua Wang王永华
  • Qianyuan Zhuang庄乾元
  • Siwei Zhou周四维
  • Zhiquan Hu胡志全
  • Ruzhu Lan兰儒竹
Article

DOI: 10.1007/s11596-009-0116-2

Cite this article as:
Wang, Y., Zhuang, Q., Zhou, S. et al. J. Huazhong Univ. Sci. Technol. [Med. Sci.] (2009) 29: 77. doi:10.1007/s11596-009-0116-2
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Summary

B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in tumor immune escape by inducing T-cell apoptosis. In order to investigate the relationship between B7-H1 and immune escape of bladder cancer, B7-H1 expression in 50 cases of bladder cancer was detected by using immunohistochemical method. Survival curves were constructed using the Kaplan-Meier method and independent prognostic factors were evaluated using the Cox regression model. Our results showed that the positive rate of B7-H1 immunostaining in normal bladder tissue and bladder cancer was 0 and 72% respectively. The expression of B7-H1 was strongly associated with the pathological grade, clinical stage and recurrence (P<0.05). The survival rate was significantly lower in patients with B7-H1 positive group than in those with B7-H1 negative group and multi-variable analysis revealed that B7-H1 could be regarded as an independent factor in evaluating the prognosis of bladder cancer. It is concluded that the expression of B7-H1 is strongly associated with neoplastic progression and prognosis of bladder cancer. The manipulation of B7-H1 may become a beneficial target for immunotherapy in human bladder cancer.

Key words

bladder neoplasmcostimulatory moleculeB7-H1immune escape

Copyright information

© Huazhong University of Science and Technology and Springer-Verlag GmbH 2009

Authors and Affiliations

  • Yonghua Wang王永华
    • 1
  • Qianyuan Zhuang庄乾元
    • 1
  • Siwei Zhou周四维
    • 1
  • Zhiquan Hu胡志全
    • 1
  • Ruzhu Lan兰儒竹
    • 1
  1. 1.Department of Urology, Tongji Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina