Implication of EMT induced by TGF-β1 in pancreatic cancer

  • Yin Tao  (殷涛)
  • Wang Chunyou  (王春友)
  • Liu Tao  (刘涛)
  • Zhao Gang  (赵刚)
  • Zhou Feng  (周峰)
Article

DOI: 10.1007/s11596-006-0619-z

Cite this article as:
Yin, T., Wang, C., Liu, T. et al. J. Huazhong Univ. Sc. Technol. (2006) 26: 700. doi:10.1007/s11596-006-0619-z

Summary

This study examined the implication of EMT induced by TGF-β1 in pancreatic cancer invasion. TGF-β1 expression was determined in 29 cases of human pancreatic carcinoma (PC) by immunohistochemistry and the results were compared with those of pathological examination. Moreover, the effects of TGF-β1 on the phenotype and invasion of pancreatic cancer cell line Panc-1 were also investigated. TGF-β1 was detected in 12 cases (41.4 %) of PC. Significant correlation was found between the expression of TGF-β1 and lymph node involvement (P=0.047) and the depth of invasion (P=0.035). TGF-β1 obviously promoted EMT of Panc-1 cell lines and their invasion ability was substantially enhanced. TGF-β1 may promote the malignancy of pancreatic cancer by triggering EMT.

Key words

pancreatic cancer TGF-β1 EMT 

Copyright information

© Huazhong University of Science and Technology 2006

Authors and Affiliations

  • Yin Tao  (殷涛)
    • 1
  • Wang Chunyou  (王春友)
    • 1
  • Liu Tao  (刘涛)
    • 1
  • Zhao Gang  (赵刚)
    • 1
  • Zhou Feng  (周峰)
    • 1
  1. 1.Pancreatic Center, Department of General Surgery, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina