International Journal of Computer Assisted Radiology and Surgery

, Volume 4, Issue 5, pp 457–462

Comparison of diagnostic quality and accuracy in color-coded versus gray-scale DCE-MR imaging display

  • A. Mehndiratta
  • M. V. Knopp
  • C. M. Zechmann
  • M. Owsijewitsch
  • H. von Tengg-Kobligk
  • P. Zamecnik
  • H. U. Kauczor
  • P. L. Choyke
  • F. L. Giesel
Original Article

DOI: 10.1007/s11548-009-0356-4

Cite this article as:
Mehndiratta, A., Knopp, M.V., Zechmann, C.M. et al. Int J CARS (2009) 4: 457. doi:10.1007/s11548-009-0356-4

Abstract

Purpose

The purpose of this study was to evaluate the diagnostic value and tumor-vascular display properties (microcirculation) of two different functional MRI post-processing and display (color and gray-scale display) techniques used in oncology.

Materials and methods

The study protocol was approved by the IRB and written informed consent was obtained from all patients. 38 dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) data sets of patients with malignant pleural-mesothelioma were acquired and post-processed. DCE-MRI was performed at 1.5 tesla with a T1-weighted 2D gradient-echo-sequence (TR 7.0 ms, TE 3.9 ms, 15 axial slices, 22 sequential repetitions), prior and during chemotherapy. Subtracting first image of contrast-enhanced-dynamic series from the last, produced gray-scale images. Color images were produced using a pharmacokinetic two-compartment model. Eight raters, blinded to diagnosis, by visual assessment of post-processed images evaluated both diagnostic quality of the images and vasculature of the tumor using a rating scale ranging from −5 to +5. The scores for vasculature were assessed by correlating with the maximum amplitude of the total-tumor-ROI for accuracy.

Results

Color coded images were rated as significantly higher in diagnostic quality and tumor vascular score than gray-scale images (p <  0.001, 0.005). ROI signal amplitude analysis and vascular ratings on color coded images were better correlated compared to gray-scale images rating (p <  0.05).

Conclusion

Color coded images were shown to have higher diagnostic quality and accuracy with respect to tumor vasculature in DCE-MRI, therefore their implementation in clinical assessment and follow-up should be considered for wider application.

Keywords

DCE-MRIColor-coded displayGray-scale displayAngiogenesisTumor vasculature

Abbreviations

Amp

Amplitude (a.u.)

DCE-MRI

Dynamic contrast enhanced magnetic resonance imaging

kel

Elimination rate constant (min−1)

kep

Redistribution rate constant (min−1)

ROI

Region of interest

TT-ROI

Total-tumor-region of interest

Copyright information

© CARS 2009

Authors and Affiliations

  • A. Mehndiratta
    • 1
    • 2
  • M. V. Knopp
    • 4
  • C. M. Zechmann
    • 1
  • M. Owsijewitsch
    • 1
  • H. von Tengg-Kobligk
    • 1
  • P. Zamecnik
    • 1
  • H. U. Kauczor
    • 1
  • P. L. Choyke
    • 3
  • F. L. Giesel
    • 1
    • 3
  1. 1.Department of Radiology E 010German Cancer Research Center (DKFZ)HeidelbergGermany
  2. 2.School of Medical Science and TechnologyIndian Institute of Technology (IIT)KharagpurIndia
  3. 3.Clinical CenterNational Institutes of HealthBethesdaUSA
  4. 4.Department of RadiologyThe Ohio State UniversityColumbusUSA