Bulletin of Mathematical Biology

, Volume 75, Issue 8, pp 1400–1416

Modeling Intercellular Transfer of Biomolecules Through Tunneling Nanotubes

  • Yasir Suhail
  • Kshitiz
  • Justin Lee
  • Mark Walker
  • Deok-Ho Kim
  • Matthew D. Brennan
  • Joel S. Bader
  • Andre Levchenko
Original Article

DOI: 10.1007/s11538-013-9819-4

Cite this article as:
Suhail, Y., Kshitiz, Lee, J. et al. Bull Math Biol (2013) 75: 1400. doi:10.1007/s11538-013-9819-4

Abstract

Tunneling nanotubes (TNTs) have previosly been observed as long and thin transient structures forming between cells and intercellular protein transfer through them has been experimentally verified. It is hypothesized that this may be a physiologically important means of cell–cell communication. This paper attempts to give a simple model for the rates of transfer of molecules across these TNTs at different distances. We describe the transfer of both cytosolic and membrane bound molecules between neighboring populations of cells and argue how the lifetime of the TNT, the diffusion rate, distance between cells, and the size of the molecules may affect their transfer. The model described makes certain predictions and opens a number of questions to be explored experimentally.

Copyright information

© Society for Mathematical Biology 2013

Authors and Affiliations

  • Yasir Suhail
    • 1
    • 2
  • Kshitiz
    • 1
    • 3
  • Justin Lee
    • 3
  • Mark Walker
    • 1
  • Deok-Ho Kim
    • 3
  • Matthew D. Brennan
    • 1
  • Joel S. Bader
    • 1
    • 2
  • Andre Levchenko
    • 1
  1. 1.Department of Biomedical EngineeringJohns Hopkins UniversityBaltimoreUSA
  2. 2.High-Throughput Biology CenterJohns Hopkins UniversityBaltimoreUSA
  3. 3.Department of BioengineeringUniversity of WashingtonSeattleUSA

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