Targeted Oncology

, Volume 7, Issue 1, pp 69–85

A review on various targeted anticancer therapies

  • Junjie Li
  • Feng Chen
  • Marlein Miranda Cona
  • Yuanbo Feng
  • Uwe Himmelreich
  • Raymond Oyen
  • Alfons Verbruggen
  • Yicheng Ni
Review

DOI: 10.1007/s11523-012-0212-2

Cite this article as:
Li, J., Chen, F., Cona, M.M. et al. Targ Oncol (2012) 7: 69. doi:10.1007/s11523-012-0212-2
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Abstract

Translational oncology aims to translate laboratory research into new anticancer therapies. Contrary to conventional surgery, chemotherapy, and radiotherapy, targeted anticancer therapy (TAT) refers to systemic administration of drugs with particular mechanisms that specifically act on well-defined targets or biologic pathways that, when activated or inactivated, may cause regression or destruction of the malignant process, meanwhile with minimized adverse effects on healthy tissues. In this article, we intend to first give a brief review on various known TAT approaches that are deemed promising for clinical applications in the current trend of personalized medicine, and then we will introduce our newly developed approach namely small molecular sequential dual targeting theragnostic strategy as a generalized class of TAT for the management of most solid malignancies, which, after optimization, is expected to help improve overall cancer treatability and curability.

Keywords

Targeted anticancer therapy Inhibitors Monoclonal antibody Radiotherapy Small molecules 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Junjie Li
    • 1
    • 2
  • Feng Chen
    • 1
    • 2
  • Marlein Miranda Cona
    • 1
    • 2
  • Yuanbo Feng
    • 1
    • 2
  • Uwe Himmelreich
    • 1
    • 2
  • Raymond Oyen
    • 1
  • Alfons Verbruggen
    • 2
    • 3
  • Yicheng Ni
    • 1
    • 2
    • 4
  1. 1.Section of Radiology, Department of Diagnostic Sciences, Faculty of MedicineUniversity of LeuvenLeuvenBelgium
  2. 2.Molecular Small Animal Imaging Center, Faculty of MedicineUniversity of LeuvenLeuvenBelgium
  3. 3.Laboratory of Radiopharmacy, Faculty of Pharmaceutical SciencesUniversity of LeuvenLeuvenBelgium
  4. 4.Department of Radiology, Faculty of MedicineK.U. LeuvenLeuvenBelgium

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