Medical & Biological Engineering & Computing

, Volume 49, Issue 6, pp 713–718

Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses

Technical Note

DOI: 10.1007/s11517-011-0745-z

Cite this article as:
Song, J., Joshi, R.P. & Schoenbach, K.H. Med Biol Eng Comput (2011) 49: 713. doi:10.1007/s11517-011-0745-z


Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one example of a bio-process at the plasma membrane. Our study thus suggests that the use of repetitive high-intensity voltage pulses could open up possibilities for a host of synergistic bio-responses involving both thermal and electrically driven phenomena.


BioelectricVoltage pulseNanosecond, high intensityModelingThermal effect

Copyright information

© International Federation for Medical and Biological Engineering 2011

Authors and Affiliations

  1. 1.Department of Electrical and Computer Engineering and Frank Reidy Center for Bio-ElectricsOld Dominion UniversityNorfolkUSA