Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses
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- Song, J., Joshi, R.P. & Schoenbach, K.H. Med Biol Eng Comput (2011) 49: 713. doi:10.1007/s11517-011-0745-z
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Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one example of a bio-process at the plasma membrane. Our study thus suggests that the use of repetitive high-intensity voltage pulses could open up possibilities for a host of synergistic bio-responses involving both thermal and electrically driven phenomena.