Technical Note

Medical & Biological Engineering & Computing

, Volume 49, Issue 6, pp 713-718

First online:

Synergistic effects of local temperature enhancements on cellular responses in the context of high-intensity, ultrashort electric pulses

  • J. SongAffiliated withDepartment of Electrical and Computer Engineering and Frank Reidy Center for Bio-Electrics, Old Dominion University
  • , R. P. JoshiAffiliated withDepartment of Electrical and Computer Engineering and Frank Reidy Center for Bio-Electrics, Old Dominion University Email author 
  • , K. H. SchoenbachAffiliated withDepartment of Electrical and Computer Engineering and Frank Reidy Center for Bio-Electrics, Old Dominion University

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Abstract

Results of self-consistent analyses of cells show the possibility of temperature increases at membranes in response to a single nanosecond, high-voltage pulse, at least over small sections of the membrane. Molecular Dynamics simulations indicate that such a temperature increase could facilitate poration, which is one example of a bio-process at the plasma membrane. Our study thus suggests that the use of repetitive high-intensity voltage pulses could open up possibilities for a host of synergistic bio-responses involving both thermal and electrically driven phenomena.

Keywords

Bioelectric Voltage pulse Nanosecond, high intensity Modeling Thermal effect