Medical & Biological Engineering & Computing

, Volume 45, Issue 12, pp 1175–1185

An effective non-parametric method for globally clustering genes from expression profiles

Authors

    • School of Engineering and Information TechnologyDeakin University
  • Wei Shi
    • The Walter and Eliza Hall Institute of Medical Research (WEHI)
  • Gang Li
    • School of Engineering and Information TechnologyDeakin University
  • Wanlei Zhou
    • School of Engineering and Information TechnologyDeakin University
Original Article

DOI: 10.1007/s11517-007-0271-1

Cite this article as:
Hou, J., Shi, W., Li, G. et al. Med Bio Eng Comput (2007) 45: 1175. doi:10.1007/s11517-007-0271-1

Abstract

Clustering is widely used in bioinformatics to find gene correlation patterns. Although many algorithms have been proposed, these are usually confronted with difficulties in meeting the requirements of both automation and high quality. In this paper, we propose a novel algorithm for clustering genes from their expression profiles. The unique features of the proposed algorithm are twofold: it takes into consideration global, rather than local, gene correlation information in clustering processes; and it incorporates clustering quality measurement into the clustering processes to implement non-parametric, automatic and global optimal gene clustering. The evaluation on simulated and real gene data sets demonstrates the effectiveness of the algorithm.

Keywords

Bioinformatics Microarray Gene expression Clustering Data mining

Copyright information

© International Federation for Medical and Biological Engineering 2007