Journal of Neuroimmune Pharmacology

, Volume 9, Issue 3, pp 285–292

Sorting Through the Roles of Beclin 1 in Microglia and Neurodegeneration

Authors

  • Caitlin E. O’Brien
    • Cell and Molecular Biology ProgramStanford University
    • Department of Neurology and Neurological SciencesStanford University School of Medicine
    • Center for Tissue Regeneration, Repair, and RestorationVeterans Administration Palo Alto, Health Care System
    • Department of Neurology and Neurological SciencesStanford University School of Medicine
    • Center for Tissue Regeneration, Repair, and RestorationVeterans Administration Palo Alto, Health Care System
PERSPECTIVE

DOI: 10.1007/s11481-013-9519-8

Cite this article as:
O’Brien, C.E. & Wyss-Coray, T. J Neuroimmune Pharmacol (2014) 9: 285. doi:10.1007/s11481-013-9519-8

Abstract

Beclin 1 has a well-established role in regulating autophagy, a cellular degradation pathway. Although the yeast ortholog of beclin 1 (Atg6/Vps30) was discovered to also regulate vacuolar protein sorting nearly 30 years ago, the varied functions of beclin 1 in mammalian cells are only beginning to be sorted out. We recently described a role for beclin 1 in regulating recycling of phagocytic receptors in microglia, a function analogous to that of its yeast ortholog. Microglia lacking beclin 1 have a reduced phagocytic capacity, which impairs clearance of amyloid β (Aβ) in a mouse model of Alzheimer’s Disease (AD). Here we summarize these findings and discuss the implications for beclin 1-regulated receptor recycling in neurodegenerative disease.

Keywords

Beclin 1Phosphatidylinositol 3-phosphatePI3PPhosphatidylinositol 3-kinasePI3KVPS35retromerReceptor recyclingPhagocytosisAlzheimer’s DiseaseNeurodegeneration

Copyright information

© Springer Science+Business Media New York (outside the USA) 2014