Journal of Neuroimmune Pharmacology

, Volume 7, Issue 4, pp 808–819

MicroRNAs in Opioid Pharmacology

  • Cheol Kyu Hwang
  • Yadav Wagley
  • Ping-Yee Law
  • Li-Na Wei
  • Horace H. Loh
INVITED REVIEW

DOI: 10.1007/s11481-011-9323-2

Cite this article as:
Hwang, C.K., Wagley, Y., Law, P. et al. J Neuroimmune Pharmacol (2012) 7: 808. doi:10.1007/s11481-011-9323-2

Abstract

MicroRNAs (miRNA), a class of ~22-nucleotide RNA molecules, are important gene regulators that bind to the target sites of mRNAs to inhibit the gene expressions either through translational inhibition or mRNA destabilization. There are growing evidences that miRNAs have played several regulatory roles in opioid pharmacology. Like other research fields such as cancer biology, the area where numerous miRNAs are found to be involved in gene regulation, we assume that in opioid studies including research fields of drug additions and opioid receptor regulation, there may be more miRNAs waiting to be discovered. This review will summarize our current knowledge of miRNA functions on opioids biology and briefly describe future research directions of miRNAs related to opioids.

Keywords

miRNAGPCROpioid receptorFentanylMorphineAddiction

Abbreviations

Ago2

Argonaute 2

BDNF

Brain-derived neurotrophic factor

CNS

Central nervous system

CREB

cAMP-response element binding protein

CYP2D6

cytochrome P450 2D6

Drd2

Dopamine 2 receptor

Drd3

dopamine D3 receptor

ERK

Extracellular signal-regulated kinase

FGF-2

Fibroblast growth factor-2

FosB

FBJ murine osteosarcoma viral oncogene homolog B

GPCR

G protein-coupled receptor

HEK

Human embryonic kidney

HIV-1

Human immunodeficiency virus type 1

MeCP2

Methyl CpG binding protein 2

MOR

Mu opioid receptor

NeuroD

Neurogenic differentiation 1

PKA

Protein kinase A

PKC

Protein kinase C

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Cheol Kyu Hwang
    • 1
  • Yadav Wagley
    • 1
  • Ping-Yee Law
    • 1
  • Li-Na Wei
    • 1
  • Horace H. Loh
    • 1
  1. 1.Department of PharmacologyUniversity of Minnesota Medical SchoolMinneapolisUSA