Journal of Neuroimmune Pharmacology

, Volume 2, Issue 1, pp 72–80

Biomarkers for NeuroAIDS: The Widening Scope of Metabolomics

  • Gurudutt Pendyala
  • Elizabeth J. Want
  • William Webb
  • Gary Siuzdak
  • Howard S. Fox
Invited Review

DOI: 10.1007/s11481-006-9041-3

Cite this article as:
Pendyala, G., Want, E.J., Webb, W. et al. Jrnl Neuroimmune Pharm (2007) 2: 72. doi:10.1007/s11481-006-9041-3

Abstract

“Metabolomics”, the measurement of metabolite concentrations and fluxes in cell systems, is an emerging science that has enormous potential and several unique characteristics. The current applications for this field are, primarily, toxicological profiling and biomarker studies. This review of metabolomics research highlights the identification of reliable biomarkers with emphasis on neuroAIDS. Such identification of candidate markers will be advantageous for tracking the progression of human immunodeficiency virus/central nervous system (HIV/CNS) disease to gain maximal benefit from antiretroviral treatment and to provide insight into the mechanism of related neuropathogenesis.

Key words

neuroAIDSbiomarkersmetabolomicsCNSHIVSIVmass spectrometry

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Gurudutt Pendyala
    • 1
  • Elizabeth J. Want
    • 2
  • William Webb
    • 2
  • Gary Siuzdak
    • 2
  • Howard S. Fox
    • 1
  1. 1.Molecular and Integrative Neurosciences DepartmentScripps Research InstituteLa JollaUSA
  2. 2.Department of Chemistry and Center for Mass SpectrometryScripps Research InstituteLa JollaUSA