Journal of Neuroimmune Pharmacology

, Volume 2, Issue 1, pp 72–80

Biomarkers for NeuroAIDS: The Widening Scope of Metabolomics

Authors

  • Gurudutt Pendyala
    • Molecular and Integrative Neurosciences DepartmentScripps Research Institute
  • Elizabeth J. Want
    • Department of Chemistry and Center for Mass SpectrometryScripps Research Institute
  • William Webb
    • Department of Chemistry and Center for Mass SpectrometryScripps Research Institute
  • Gary Siuzdak
    • Department of Chemistry and Center for Mass SpectrometryScripps Research Institute
    • Molecular and Integrative Neurosciences DepartmentScripps Research Institute
Invited Review

DOI: 10.1007/s11481-006-9041-3

Cite this article as:
Pendyala, G., Want, E.J., Webb, W. et al. Jrnl Neuroimmune Pharm (2007) 2: 72. doi:10.1007/s11481-006-9041-3

Abstract

“Metabolomics”, the measurement of metabolite concentrations and fluxes in cell systems, is an emerging science that has enormous potential and several unique characteristics. The current applications for this field are, primarily, toxicological profiling and biomarker studies. This review of metabolomics research highlights the identification of reliable biomarkers with emphasis on neuroAIDS. Such identification of candidate markers will be advantageous for tracking the progression of human immunodeficiency virus/central nervous system (HIV/CNS) disease to gain maximal benefit from antiretroviral treatment and to provide insight into the mechanism of related neuropathogenesis.

Key words

neuroAIDSbiomarkersmetabolomicsCNSHIVSIVmass spectrometry

Copyright information

© Springer Science+Business Media, Inc. 2006