Plasmonics

, Volume 7, Issue 4, pp 717–724

Gold Nanoparticle Uptake by Tumour Cells of B16 Mouse Melanoma

  • Marioara Avram
  • Cătălin Mihai Bălan
  • Ina Petrescu
  • Vasilica Schiopu
  • Cătălin Mărculescu
  • Andrei Avram
Article

DOI: 10.1007/s11468-012-9363-3

Cite this article as:
Avram, M., Bălan, C.M., Petrescu, I. et al. Plasmonics (2012) 7: 717. doi:10.1007/s11468-012-9363-3

Abstract

Because of their photo-optical distinctiveness and biocompatibility, gold nanoparticles have proven to be powerful tools in various nanomedical applications. In this article, we discuss the advantage of gold nanoparticles in image diagnostic application of melanoma. It has demonstrated the potential role of gold nanoparticles in the study of tumour tissue architecture and the utility of gold nanoparticles in the hystopathological exam of B16 melanoma with the benefit of fluorescence emission of gold nanoparticles in UV spectrum. The optical properties of colloidal gold nanoparticles allow spectroscopic detection and identification of melanoma cells. The method proposed is easy, inexpensive and reliable for hystopathological analysis of melanoma. The fluorescence images in the cryosections of tissues depicted a strong luminescence property of gold nanoparticles uptaken in melanoma, results that confirm the role of the gold nanoparticles in biological labelling and imaging applications. To emphasize the AuNPs influence over the biological tissues, a study of the chemical bonds configuration was performed using Raman spectrometry.

Keywords

B16 melanomaUV spectrumGold nanoparticlesPlasmon resonance

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Marioara Avram
    • 1
  • Cătălin Mihai Bălan
    • 1
  • Ina Petrescu
    • 2
  • Vasilica Schiopu
    • 1
  • Cătălin Mărculescu
    • 1
  • Andrei Avram
    • 1
    • 3
  1. 1.L10 Micro and Nano Fluidics LaboratoryNational Institute for Research and Development in MicrotechnologiesBucharestRomania
  2. 2.Department of Plastic Surgery and Reconstructive MicrosurgeryEmergency University HospitalBucharestRomania
  3. 3.Politehnica University of BucharestBucharestRomania