Plasmonics

, Volume 4, Issue 2, pp 187–192

SERS Study of Tetrodotoxin (TTX) by Using Silver Nanoparticle Arrays

Authors

  • Wen-Chi Lin
    • Institute of Optoelectronic SciencesNational Taiwan Ocean University
  • Hsiao-Chin Jen
    • Institute of Food SciencesNational Taiwan Ocean University
  • Chang-Long Chen
    • Institute of Optoelectronic SciencesNational Taiwan Ocean University
  • Deng-Fwu Hwang
    • Institute of Food SciencesNational Taiwan Ocean University
  • Railing Chang
    • Institute of Optoelectronic SciencesNational Taiwan Ocean University
  • Jih-Shang Hwang
    • Institute of Optoelectronic SciencesNational Taiwan Ocean University
    • Institute of Optoelectronic SciencesNational Taiwan Ocean University
    • Institute of PhysicsAcademia Sinica
Article

DOI: 10.1007/s11468-009-9090-6

Cite this article as:
Lin, W., Jen, H., Chen, C. et al. Plasmonics (2009) 4: 187. doi:10.1007/s11468-009-9090-6

Abstract

The optical properties of tetrodotoxin (TTX), a scarce toxin with anesthetic properties, were studied using nanoparticle arrays-assisted surface-enhanced Raman scattering (SERS). The nanoparticles arrays were fabricated using nanosphere lithography and a metallic lift-off process to control the particle size, shape, and spacing in the arrays. Using density functional methods, the Raman spectrum of TTX was also calculated with Gaussian03 software. The main peaks of the spectrum are originated from the vibration of the NH2 molecule group. In the SERS experiment, we were able to measure the Raman spectrum with a TTX concentration as less as 0.9 ng/mL. This sensitivity is comparable to that from high performance liquid chromatography.

Keywords

Surface enhaced Raman scattering (SERS)Tetrodotoxin (TTX)Nanosphere lithography (NSL)Ag nanoparticle arraysDensity functional theory (DFT)

Copyright information

© Springer Science+Business Media, LLC 2009