Plasmonics

, Volume 2, Issue 4, pp 173–183

Gold Nanoparticle Based FRET for DNA Detection

Authors

    • Department of ChemistryJackson State University
  • Gopala Krishna Darbha
    • Department of ChemistryJackson State University
  • Anandhi Ray
    • Department of ChemistryJackson State University
  • Joshua Walker
    • Department of ChemistryJackson State University
  • William Hardy
    • Department of ChemistryJackson State University
Article

DOI: 10.1007/s11468-007-9036-9

Cite this article as:
Ray, P.C., Darbha, G.K., Ray, A. et al. Plasmonics (2007) 2: 173. doi:10.1007/s11468-007-9036-9

Abstract

The nanoscience revolution that sprouted throughout the 1990s is having great impact in current and future DNA detection technology around the world. In this review, we report our recent progress on gold nanoparticle based fluorescence resonance energy transfer assay to monitor DNA hybridization as well as the cleavage of DNA by nucleases. We tried to discuss a reasonable account of the science and the important fundamental work carried out in this area. We also report the development of a compact, highly specific, inexpensive and user-friendly optical fiber laser-induced fluorescence sensor based on fluorescence quenching by nanoparticles to detect single-strand DNA hybridization at femtomolar level.

Keywords

Gold nanoparticleFRETDNA detectionSensor

Copyright information

© Springer Science+Business Media, LLC 2007