Frontiers of Chemistry in China

, Volume 5, Issue 4, pp 357–422

A golden phoenix arising from the herbal nest — A review and reflection on the study of antimalarial drug Qinghaosu

Authors

    • Department of Medicinal Chemistry, Shanghai Institute of Materia MedicaChinese Academy of Sciences
    • State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic ChemistryChinese Academy of Sciences
Feature Article

DOI: 10.1007/s11458-010-0214-5

Cite this article as:
Li, Y. & Wu, Y. Front. Chem. China (2010) 5: 357. doi:10.1007/s11458-010-0214-5

Abstract

Qinghaosu (QHS) and its derivatives are a new generation of antimalarial drugs characterized by fast action, high efficacy, and good tolerance. This feature article states the discovery of QHS from traditional Chinese medicine qinghao (Artemisia annua L.) and reviews the progress during the past four decades in the research of phytochemistry of A. annua, chemical reactions and biotransformation of QHS, chemical synthesis and biosynthesis of QHS, synthesis and antimalarial activity of QHS derivatives and analogs, pharmacological studies, clinical application, and the antimalarial mechanism. Undoubtedly, QHS is an example of the value of traditional Chinese medicine in modern medicinal research.

Copyright information

© Higher Education Press and Springer-Verlag Berlin Heidelberg 2010