Chinese Science Bulletin

, Volume 59, Issue 13, pp 1355–1361

A potential ethnic difference in the association between 5-HTTLPR polymorphisms and the brain default mode network

Invited Article Genetics

DOI: 10.1007/s11434-014-0185-x

Cite this article as:
Long, H., Liu, B., Hou, B. et al. Chin. Sci. Bull. (2014) 59: 1355. doi:10.1007/s11434-014-0185-x


The serotonin-transporter-linked polymorphic region (5-HTTLPR) is associated with mood disorders. This association is thought to be due to amygdala hyperresponsiveness to negative emotional stimuli as a result of reduced frontal cortical control. In Caucasians, the short form is associated with this effect, but in Han Chinese we recently found that the long form is involved. Serotonin receptors have rich expression in default mode network (DMN) regions and the recent studies have found an association between the short form of the 5-HTTLPR and DMN functional connectivity (FC) in Caucasians. The present study has investigated whether there may also be an ethnic difference in this influence of 5-HTTLPR on the DMN. We recruited 233 young Han Chinese subjects and calculated the resting-state default-network FC. Our study found that the L carriers had decreased FC in the bilateral medial prefrontal cortex, right parahippocampal gyrus, left middle temporal gyrus, and increased FC in left precuneus (Pcu) compared to SS. The PCC-Pcu FC in L carriers was significantly negatively correlated with the depression scores. Our findings, therefore, suggest that there is also a difference between Caucasian and Han Chinese subjects in the association between the different forms of the 5-HTTLPR and DMN functional connectivity.


5-HTTLPR Default mode network Ethnic difference Resting-state functional connectivity 

Copyright information

© Science China Press and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Haixia Long
    • 1
    • 2
  • Bing Liu
    • 1
    • 2
  • Bing Hou
    • 1
    • 2
  • Chao Wang
    • 3
  • Keith M. Kendrick
    • 3
  • Chunshui Yu
    • 4
  • Tianzi Jiang
    • 1
    • 2
    • 3
    • 5
  1. 1.Brainnetome Center, Institute of AutomationChinese Academy of SciencesBeijingChina
  2. 2.National Laboratory of Pattern Recognition, Institute of AutomationChinese Academy of SciencesBeijingChina
  3. 3.Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengduChina
  4. 4.Department of RadiologyTianjin Medical University General HospitalTianjinChina
  5. 5.Queensland Brain InstituteUniversity of QueenslandBrisbaneAustralia

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