Chinese Science Bulletin

, Volume 58, Issue 35, pp 4362–4370

Current status of research and application in vascular stents

  • PengKai Qi
  • Ying Yang
  • F. Manfred Maitz
  • Nan Huang
Open AccessReview Special Topic 9th World Biomaterials Congress: Innovative Biomaterials and Crossing Frontiers in Biomaterials and Regenerative M

DOI: 10.1007/s11434-013-6070-1

Cite this article as:
Qi, P., Yang, Y., Maitz, F.M. et al. Chin. Sci. Bull. (2013) 58: 4362. doi:10.1007/s11434-013-6070-1
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Abstract

Cardiovascular diseases have been the leading cause of death in modern society. Using vascular stents to treat these coronary and peripheral artery diseases has been one of the most effective and rapidly adopted medical interventions. During the twenty-five years’ development of vascular stents, revolutionary cardiovascular stents like drug eluting stents and endothelial progenitor cells capture stents have emerged. In this review, the evolution of vascular stents is summarized, aiming to provide a glimpse into the future of vascular stents. Advanced designs, focusing on the investigations of new substrates, new platforms, new drugs and new biomolecules are currently under evaluation with promising clinical studies. The concept of “time sequence functional stent” has been raised in this paper. It presents anti-proliferative properties in the first phase after implantation and subsequently support endothelialization. It also shows long-term inertness without release of toxic ions or toxic degradation products. The success of this concept is briefly presented with a clinical study in this model stents.

Keywords

bare metal stentdrug eluting stentbiodegradable stentEPC-capture stentendothelialization
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Copyright information

© The Author(s) 2013

Authors and Affiliations

  • PengKai Qi
    • 1
    • 3
  • Ying Yang
    • 1
    • 3
  • F. Manfred Maitz
    • 2
    • 3
  • Nan Huang
    • 1
    • 3
  1. 1.Key Laboratory of Advanced Technology of Materials of Education MinistrySouthwest Jiaotong UniversityChengduChina
  2. 2.Max Bergmann Center of Biomaterials DresdenLeibniz Institute of Polymer Research DresdenDresdenGermany
  3. 3.School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduChina