Chinese Science Bulletin

, Volume 56, Issue 21, pp 2191–2201

Evolution and molecular epidemiology of foot-and-mouth disease virus in China

Authors

    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
  • PingHua Li
    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
  • Dong Li
    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
  • ZengJun Lu
    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
  • YiMei Cao
    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
  • YouJun Shang
    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
  • JunJun Shao
    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
  • HuiYun Chang
    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
  • JianXun Luo
    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
  • XiangTao Liu
    • State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research InstituteChinese Academy of Agricultural Sciences
Open AccessReview Virology

DOI: 10.1007/s11434-011-4563-3

Cite this article as:
Bai, X., Li, P., Bao, H. et al. Chin. Sci. Bull. (2011) 56: 2191. doi:10.1007/s11434-011-4563-3

Abstract

Foot-and-mouth disease (FMD), caused by foot-and-mouth disease virus (FMDV), is considered one of the most important viral diseases of cloven-hoofed animals, causing severe economic losses in affected regions of the world. Three serotypes (A, O, and Asia 1) of FMDV have been identified in China since 1958. In addition, the occurrence of novel subtypes within these serotypes has made the epidemiology of FMDV more complicated over the last few years. In this review, we summarize the history and the current epidemiological situation in China, genetic diversity (e.g., quasispecies dynamics, antigenic heterogeneity, and functional constraints), intertypic recombination, and the evidence for positive selection of different FMDV serotypes. We also assess these genetic data to understand the origin, evolution, and transmission of FMDV, the findings of which may be useful in developing control measures for future epidemics.

Keywords

foot-and-mouth disease virusphylogenetic analysisrecombinationpositive selection
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© The Author(s) 2011

Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.