Chinese Science Bulletin

, Volume 54, Issue 11, pp 1912–1917

Synthesis and micellization behavior of stimuli-responsive polypeptide hybrid triblock copolymer

Articles/Polymer Chemistry

DOI: 10.1007/s11434-009-0244-x

Cite this article as:
Rao, J., Zhu, Z. & Liu, S. Chin. Sci. Bull. (2009) 54: 1912. doi:10.1007/s11434-009-0244-x


Polypeptide hybrid triblock copolymer, poly(L-glutamic acid)-b-poly(propylene oxide)-b-poly (L-glutamic acid) (PLGA-b-PPO-b-PLGA), was synthesized by the ring-opening polymerization of benzyl-L-glutamic N-carboxyanhydride (BLG-NCA) using poly(propylene glycol) bis(2-aminopropyl ether) as initiator, followed by the subsequent deprotection step. The obtained double hydrophilic triblock copolymer exhibits “schizophrenic” micellization behavior in aqueous solution upon dually playing with solution pH and temperature. The multi-responsive micellization behavior of this polypeptide hybrid triblock copolymer has been thoroughly investigated by 1H NMR, laser light scattering (LLS), temperature-dependent optical transmittance, and circular dichroism spectroscopy (CD).


poly(L-glutamic acid)poly(propylene glycol)coilα-helixmicellization

Copyright information

© Science in China Press and Springer-Verlag GmbH 2009

Authors and Affiliations

  1. 1.Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and EngineeringUniversity of Science and Technology of ChinaHefeiChina