, Volume 53, Issue 10, pp 1457-1467
Date: 15 Jun 2008

Positive Darwinian selection in human population: A review

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This paper reviews a large number of genes under positive Darwinian selection in modern human populations, such as brain development genes, immunity genes, reproductive related genes, perception receptors. The research on the evolutionary property of these genes will provide important insight into human evolution and disease mechanisms. With the increase of population genetics and comparative genomics data, more and more evidences indicate that positive Darwinian selection plays an indispensable role in the origin and evolution of human beings. This paper will also summarize the methods to detect positive selection, analyze the interference factors faced and make suggestions for further research on positive selection.

Supported by the National Natural Science Foundation of China (Grant Nos. 30621092 and 30430110), and Bureau of Science and Technology of Yunnan Province