Chinese Science Bulletin

, Volume 53, Issue 5, pp 709–717

Advances in the study on induced pluripotent stem cells

Review Cell Biology

DOI: 10.1007/s11434-008-0152-5

Cite this article as:
Liu, S. & Duan, E. Chin. Sci. Bull. (2008) 53: 709. doi:10.1007/s11434-008-0152-5


Recently, the study on “induced pluripotent stem cells” (iPS cells) has made a great breakthrough, and it is considered as a new milestone in the history of life science. This progress has updated our traditional concepts about pluripotency control, and provided people with a brand-new strategy for somatic cell nuclear reprogramming. In virtue of its availability and stability, this method holds great potential in both biological and clinical research. In order to introduce this rising field of study, this paper starts with an overview of the development of iPS cell establishment, describes the key steps in generating iPS cells, elaborates several relevant scientific issues, and evaluates its current restrictions and promises in future research.


induced pluripotent stem cells reprogramming pluripotency embryonic stem cells differentiation 

Copyright information

© Science in China Press 2008

Authors and Affiliations

  1. 1.State Key Laboratory of Reproductive Biology, Institute of ZoologyChinese Academy of SciencesBeijingChina
  2. 2.Graduate University of the Chinese Academy of SciencesBeijingChina

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