Articles Polymer Chemistry

Chinese Science Bulletin

, Volume 53, Issue 8, pp 1165-1170

Preparation of monodisperse, superparamagnetic, luminescent, and multifunctional PGMA microspheres with amino-groups

  • WeiCai WangAffiliated withInstitute of Nanobiotechnology, School of Materials Science & Engineering, Tianjin University
  • , Qi ZhangAffiliated withInstitute of Nanobiotechnology, School of Materials Science & Engineering, Tianjin University
  • , BingBo ZhangAffiliated withInstitute of Nanobiotechnology, School of Materials Science & Engineering, Tianjin University
  • , DeNa LiAffiliated withInstitute of Nanobiotechnology, School of Materials Science & Engineering, Tianjin University
  • , XiaoQing DongAffiliated withInstitute of Nanobiotechnology, School of Materials Science & Engineering, Tianjin University
  • , Lei ZhangAffiliated withInstitute of Nanobiotechnology, School of Materials Science & Engineering, Tianjin University
  • , Jin ChangAffiliated withInstitute of Nanobiotechnology, School of Materials Science & Engineering, Tianjin University Email author 

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Abstract

Micron-sized, monodisperse, superparamagnetic, luminescent composite poly(glycidyl methacrylate) (PGMA) microspheres with functional amino-groups were successfully synthesized in this study. The process of preparation was as follows: preparation of monodisperse poly(glycidyl methacrylate) microspheres by dispersion polymerization method; modification of poly(glycidyl methacrylate) microspheres with ethylene diamine to form amino-groups; impregnation of iron ions (Fe2+ and Fe3+) inside the microspheres and subsequently precipitating them with ammonium hydroxide to form magnetite (Fe3O4) nanoparticles within the polymer microspheres; infusion of CdSe/CdS core-shell quantum dots (QDs) into magnetic polymer microspheres. Scanning electron microscopy (SEM) was used to characterize surface morphology and size distribution of composite microspheres. The average size of microspheres was 1.42 μm with a size variation of 3.8%. The composite microspheres were bright enough and easily observed using a conventional fluorescence microscope. The composite microspheres were easily separated from solution by magnetic decantation using a permanent magnet. The new multifunctional composite microspheres are promising to be used in a variety of bioanalytical assays involving luminescence detection and magnetic separation.

Key words

luminescence magnetism glycidyl methacrylate quantum dots multifunction