Science China Life Sciences

, Volume 56, Issue 11, pp 1014–1019

Frequency of HLA-A*03 associates with HIV-1 infection in a Chinese cohort

Authors

  • WeiLun Zhang
    • Institute of Basic Medical SciencesChinese Academy of Medical Sciences & Peking Union Medical College
  • Li Wang
    • Institute of Basic Medical SciencesChinese Academy of Medical Sciences & Peking Union Medical College
  • KunXue Hong
    • State Key Laboratory for Infectious Disease Prevention and ControlNational Center for AIDS/STD Control and Prevention
  • YanXin Liu
    • Institute of Basic Medical SciencesChinese Academy of Medical Sciences & Peking Union Medical College
  • Bing Su
    • Anhui Center for Disease Control and Prevention
  • Cheng Xu
    • Fuyang Center for Disease Control and Prevention
  • JianQin Xu
    • State Key Laboratory for Infectious Disease Prevention and ControlNational Center for AIDS/STD Control and Prevention
  • YuHua Ruan
    • State Key Laboratory for Infectious Disease Prevention and ControlNational Center for AIDS/STD Control and Prevention
    • State Key Laboratory for Infectious Disease Prevention and ControlNational Center for AIDS/STD Control and Prevention
    • Institute of Basic Medical SciencesChinese Academy of Medical Sciences & Peking Union Medical College
Open AccessResearch Paper

DOI: 10.1007/s11427-013-4555-4

Cite this article as:
Zhang, W., Wang, L., Hong, K. et al. Sci. China Life Sci. (2013) 56: 1014. doi:10.1007/s11427-013-4555-4

Abstract

During the early mid-1990s, a number of rural farmers across central China were employed to the unregulated plasmaselling-activity and many of them were infected by HIV-1. However, AIDS progression in the former blood donors (FBDs) is various. The aim of this study is to assess human leukocyte antigen (HLA) class I allele distribution in FBDs and evaluate its association with HIV-1 infection and disease progression. A total of 353 FBDs were enrolled in the cohort including 294 ART naïve HIV-1 seropositive and 59 HIV-1 seronegative age-matched subjects. The viral load and CD4/CD8 T cell counts were assessed in all subjects. Compared with HIV-seropositive group, the frequency of HLA-A*03 in control was significantly higher. After classifying the HLA-B alleles of the subjects according to the presence of Bw4/Bw6 serological epitopes, detrimental effect of HLA Bw6/ Bw6 homozygosity was also confirmed in the HIV-seropositive subjects. This study provides novel evidence on HLA class I allele distribution and association of HLA-A*03 frequency with HIV-1 infection and viremia in the HIV-1 infected FBDs, which may throw light on intervention strategy for the HIV-1 infection and our understanding how host immunity and genetic background affect HIV infection and AIDS progression.

Keywords

leukocyte antigen class IHIV-1 infectionviremia controlChinese former blood donor cohort
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Copyright information

© The Author(s) 2013