Science China Life Sciences

, Volume 56, Issue 9, pp 780–787

The molecular basis for ethnic variation and histological subtype differences in prostate cancer

Open Access
Review CUSBEA Article Series

DOI: 10.1007/s11427-013-4522-0

Cite this article as:
Zong, Y., Goldstein, A.S. & Huang, J. Sci. China Life Sci. (2013) 56: 780. doi:10.1007/s11427-013-4522-0


Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate cancer increase dramatically in several oriental countries including China. Rapidly evolving technology in molecular biology such as high-throughput sequencing and integrative analysis of genomic and transcriptomic landscapes have enabled the identification of key oncogenic events for prostate cancer initiation, progression and resistance to hormonal therapy. These surging data of prostate cancer genome also provide insights on ethnic variation and the differences in histological subtype of this disease. In this review, differences in the incidence of prostate cancer and the prevalence of main genetic alterations between Asian and Western populations are discussed. We also review the recent findings on the mechanisms underlying neuroendocrine differentiation of prostate cancer and the development of small cell neuroendocrine carcinoma after androgen deprivation therapy.


prostate cancer castration resistance neuroendocrine differentiation small cell neuroendocrine carcinoma 
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Copyright information

© The Author(s) 2013

Authors and Affiliations

  • Yang Zong
    • 1
  • Andrew S. Goldstein
    • 2
    • 4
    • 5
    • 6
  • JiaoTi Huang
    • 3
    • 4
    • 5
    • 6
  1. 1.Howard Hughes Medical InstituteUniversity of CaliforniaLos AngelesUSA
  2. 2.Departments of Molecular and Medical PharmacologyUniversity of CaliforniaLos AngelesUSA
  3. 3.Pathology and Laboratory medicineUniversity of CaliforniaLos AngelesUSA
  4. 4.UrologyUniversity of CaliforniaLos AngelesUSA
  5. 5.Jonsson Comprehensive Cancer Center, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA
  6. 6.Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell ResearchUniversity of CaliforniaLos AngelesUSA

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