Science China Life Sciences

, Volume 55, Issue 6, pp 533–541

Protein photo-folding and quantum folding theory

Open Access
Research Paper

DOI: 10.1007/s11427-012-4316-9

Cite this article as:
Luo, L. Sci. China Life Sci. (2012) 55: 533. doi:10.1007/s11427-012-4316-9

Abstract

The rates of protein folding with photon absorption or emission and the cross section of photon -protein inelastic scattering are calculated from quantum folding theory by use of a field-theoretical method. All protein photo-folding processes are compared with common protein folding without the interaction of photons (non-radiative folding). It is demonstrated that there exists a common factor (thermo-averaged overlap integral of the vibration wave function, TAOI) for protein folding and protein photo-folding. Based on this finding it is predicted that (i) the stimulated photo-folding rates and the photon-protein resonance Raman scattering sections show the same temperature dependence as protein folding; (ii) the spectral line of the electronic transition is broadened to a band that includes an abundant vibration spectrum without and with conformational transitions, and the width of each vibration spectral line is largely reduced. The particular form of the folding rate—temperature relation and the abundant spectral structure imply the existence of quantum tunneling between protein conformations in folding and photo-folding that demonstrates the quantum nature of the motion of the conformational-electronic system.

Keywords

protein folding dynamics photo-folding conformational change quantum transition 
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Copyright information

© The Author(s) 2012

Authors and Affiliations

  1. 1.Faculty of Physical Science and TechnologyInner Mongolia UniversityHohhotChina

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