Science China Life Sciences

, Volume 54, Issue 3, pp 235–239

Simple diffusion delivery via brain interstitial route for the treatment of cerebral ischemia

Authors

    • Department of RadiologyPeking University Third Hospital
    • Department of Neurology, Affiliated HospitalTaishan Medical College
  • He Chen
    • Department of RadiologyPeking University Third Hospital
  • Chao Hou
    • Department of RadiologyPeking University Third Hospital
  • WeiBo Li
    • Department of Medical Radiation Physics and Diagnostics, Helmholtz Zentrum MünchenGerman Research Center for Environmental Health (GmbH)
Open AccessResearch Papers

DOI: 10.1007/s11427-011-4141-6

Cite this article as:
Han, H., Xia, Z., Chen, H. et al. Sci. China Life Sci. (2011) 54: 235. doi:10.1007/s11427-011-4141-6

Abstract

Delivering pharmacologic agents directly into the brain has been proposed as a means of bypassing the blood brain barrier. However, despite 16 years of research on a number of central nervous system disorders, an effective treatment using this strategy has only been observed in the brain tumor glioblastoma multiforme. Within this study we propose a novel system for delivering drugs into the brain named the simple diffusion (SDD) system. To validate this technique, rats were subjected to a single intracranial (at the caudate nucleus), or intraperitoneal injection, of the compound citicoline, followed two hours later by a permanent middle cerebral artery occlusion (pMCAO). Results showed that 12 h after pMCAO, with 0.0025 g kg−1 citicoline, an infarct volume 1/6 the size of the intraperitoneal group was achieved with a dose 1/800 of that required for the intraperitoneal group. These results suggest that given the appropriate injection point, through SDD a pharmacologically effective concentration of citicoline can be administered.

Keywords

permanent middle cerebral artery occlusionanimal modelbrain ischemic injuryciticoline therapyMRIneuroprotection
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© The Author(s) 2011

This article is published under license to BioMed Central Ltd. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution and reproduction in any medium, provided the original author(s) and source are credited.