Science China Life Sciences

, Volume 53, Issue 2, pp 159–168

TRAF-mediated regulation of immune and inflammatory responses

  • YaYa Wang
  • Peng Zhang
  • YingFang Liu
  • GenHong Cheng
Special Topic Review

DOI: 10.1007/s11427-010-0050-3

Cite this article as:
Wang, Y., Zhang, P., Liu, Y. et al. Sci. China Life Sci. (2010) 53: 159. doi:10.1007/s11427-010-0050-3

Abstract

The tumor necrosis factor (TNF) receptor-associated factor (TRAF) family consists of six mammalian members, and is shown to participate in signal transduction of a large number of receptor families including TNF receptor family (TNFR) and Toll-like receptors-interleukin-1 receptors (TLR-IL-1R) family. Upon receptor activation, TRAFs are directly or indirectly recruited to the intracellular domains of these receptors. They subsequently engage other signaling proteins to activate inhibitor of κB kinase (IKK) complex, TRAF family member-associated NF-κB activator (TANK)-binding kinase 1 (TBK1) and inducible I κB kinase (IKK-i) (also known as IKKɛ), ultimately leading to activation of transcription factors such as NF-κB and interferon-regulatory factor (IRF) to induce immune and inflammatory responses.

Keywords

TRAF NF-κB type 1 interferon innate immunity 

Copyright information

© Science in China Press and Springer-Verlag Berlin Heidelberg 2010

Authors and Affiliations

  • YaYa Wang
    • 1
  • Peng Zhang
    • 2
  • YingFang Liu
    • 2
  • GenHong Cheng
    • 1
  1. 1.Department of Microbiology, Immunology & Molecular GeneticsUniversity of California Los AngelesLos AngelesUSA
  2. 2.National Laboratory of Biomacromolecules, Institute of BiophysicsChinese Academy of SciencesBeijingChina

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