Articles

Science China Chemistry

, Volume 56, Issue 5, pp 595-603

New strategy for reversing biofilm-associated antibiotic resistance through ferrocene-substituted carborane ruthenium(II)-arene complex

  • ShuiHong LiAffiliated withState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University
  • , ChangYu WuAffiliated withState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University
  • , Xiao TangAffiliated withSchool of Chemistry and Chemical Engineering, Nanjing University
  • , ShengPing GaoAffiliated withState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University
  • , XinQing ZhaoAffiliated withSchool of Life Science and Biotechnology, Dalian University of Technology
  • , Hong YanAffiliated withSchool of Chemistry and Chemical Engineering, Nanjing University
  • , XueMei WangAffiliated withState Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University Email author 

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Abstract

Bacterial biofilms are inherently resistant to antimicrobial agents and are difficult to eradicate with conventional antimicrobial agents, resulting in many persistent and chronic bacterial infections. In this contribution, a new strategy for reversing the biofilm-associated antibiotic resistance has been explored by induction of a carborane ruthenium(II)-arene complex (FcRuSB). Our results demonstrate that the FcRuSB could be utilized as an inducer to efficiently reverse the biofilm-associated antibiotic resistance of multidrug-resistant (MDR) clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa. The induced effect of FcRuSB is correlated with a considerable decrease in the expression of extracellular matrix proteins (EMP) of the two strains. The considerable decrease of the EMP of induced cells, resulting in the reduction of adherence and biofilm formation ability of the two types of MDR pathogens, and then can cause significantly enhanced sensitivity of them to antibiotics.

Keywords

bacterial biofilms carborane ruthenium(II)-arene complex antibiotic resistance