Science China Chemistry

, Volume 56, Issue 5, pp 595–603

New strategy for reversing biofilm-associated antibiotic resistance through ferrocene-substituted carborane ruthenium(II)-arene complex

  • ShuiHong Li
  • ChangYu Wu
  • Xiao Tang
  • ShengPing Gao
  • XinQing Zhao
  • Hong Yan
  • XueMei Wang
Articles

DOI: 10.1007/s11426-012-4812-6

Cite this article as:
Li, S., Wu, C., Tang, X. et al. Sci. China Chem. (2013) 56: 595. doi:10.1007/s11426-012-4812-6

Abstract

Bacterial biofilms are inherently resistant to antimicrobial agents and are difficult to eradicate with conventional antimicrobial agents, resulting in many persistent and chronic bacterial infections. In this contribution, a new strategy for reversing the biofilm-associated antibiotic resistance has been explored by induction of a carborane ruthenium(II)-arene complex (FcRuSB). Our results demonstrate that the FcRuSB could be utilized as an inducer to efficiently reverse the biofilm-associated antibiotic resistance of multidrug-resistant (MDR) clinical isolates of Staphylococcus aureus and Pseudomonas aeruginosa. The induced effect of FcRuSB is correlated with a considerable decrease in the expression of extracellular matrix proteins (EMP) of the two strains. The considerable decrease of the EMP of induced cells, resulting in the reduction of adherence and biofilm formation ability of the two types of MDR pathogens, and then can cause significantly enhanced sensitivity of them to antibiotics.

Keywords

bacterial biofilmscarborane ruthenium(II)-arene complexantibiotic resistance

Copyright information

© Science China Press and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • ShuiHong Li
    • 1
  • ChangYu Wu
    • 1
  • Xiao Tang
    • 2
  • ShengPing Gao
    • 1
  • XinQing Zhao
    • 3
  • Hong Yan
    • 2
  • XueMei Wang
    • 1
  1. 1.State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory)Southeast UniversityNanjingChina
  2. 2.School of Chemistry and Chemical EngineeringNanjing UniversityNanjingChina
  3. 3.School of Life Science and BiotechnologyDalian University of TechnologyDalianChina