Total Hip Arthroplasty at the Rothman Institute
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- Austin, M.S., Higuera, C.A. & Rothman, R.H. HSS Jrnl (2012) 8: 146. doi:10.1007/s11420-012-9268-x
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Total hip arthroplasty (THA) is one of the most successful surgical interventions devised in modern times. Attempts to change the current THA procedure with unproven innovations bring the risk of increased failure rates while trying to improve the benefit of the surgery.
This manuscript examines the evolution of THA at the Rothman Institute illustrating the key elements that lead the success of this procedure at this institution. These key elements include femoral stem design, use of highly crossed-linked polyethylene and use of pain and rehabilitation protocols. We attempted to describe the long-term results regarding safety, effectiveness, and durability of specific THA implant designs used at this institution drawing on reported evidence in the literature.
The authors performed a review of peer-reviewed articles related to the Rothman Institute’s experience with THA.
Total hip arthroplasty is an efficient, safe, and durable procedure. It is a highly successful operation to restore function and improve pain. The survivorship of THA procedures at the Rothman Institute is higher than 99% at 10 years based on mechanical failure. The use of collarless, tapered wedge femoral stem, highly crossed-linked polyethylene, and improved pain rehabilitation protocols have contributed to this success.
There is a well-documented long-term survivorship after THA. Future innovation in THA should address new challenges with younger and more demanding patients, rather than change current methods that have a proven good survivorship. This innovation depends mainly upon improvements in the bearing surfaces and advances in pain control and rehabilitation.
Total hip arthroplasty (THA) is a highly successful operation that is the gold standard for surgical treatment of end-stage degenerative joint disease of the hip . The procedure will be performed 572,000 times in the USA alone by the year 2030 according to Kurtz et al. . Studies from the Rothman Institute have demonstrated survivorship of >99% at long-term follow-up [24, 33, 34]. There are three main areas where significant elements have contributed to the long-term survivorship and good clinical outcomes of this procedure including: specific femoral stem implants (collarless, tapered wedge), advancements in the bearing surfaces (highly crossed-linked polyethylene) and improvements of perioperative pain management and rehabilitation protocols.
This manuscript describes the evolution of total hip arthroplasty at the Rothman Institute and aims to illustrate the main characteristics of implants, bearing surfaces, and changes on pain and rehabilitation protocols that lead to successful long-term results. Additionally, the long-term results regarding safety, effectiveness, and durability of specific designs used at this institution are reported. Given the good long-term results after THA, attempts to change the current procedure with no proven or long-term followed innovations may backfire risking higher failure rates while trying to increase the benefit of the surgery.
Search Strategy and Criteria
The PubMed database was used to search relevant articles from the Rothman Institute related to THA outcomes. The searching criteria included [Rothman] and [hip arthroplasty]. This initial search showed 154 manuscripts. From those, only THA cohort studies describing outcomes and survivorship of the different implants that have been used at this institution were included. Additionally, papers related to pain management and rehabilitation protocols were included as well. A total of 27 manuscripts were included in the final review.
The criteria for the use of any surgical implant should be focused on safety, effectiveness, and durability. The effectiveness of THA is measured by pain and functional outcome. Two studies comparing the effectiveness of different stems performed at our institution were found [9, 11]. A matched pair analysis comparing the tapered, wedged design to the Charnley design at 2–5-year follow-up demonstrated no significant difference in pain or functional outcome scores . In a study of 36 staged bilateral hip arthroplasty using the Charnley design in one side and tapered, wedge design in the other side, patient preference was evaluated . Seventy-eight percent of patients either preferred the cementless design or had no preference. Twenty-two percent of patients preferred the cemented design.
The bearing surface options available for modern THA include metal-on-highly crossed-linked polyethylene, ceramic-on-highly cross-linked polyethylene, ceramic-on-ceramic, and metal-on-metal. The bearing surface has traditionally been the rate limiting step in longevity of the modern THA construct. While cementless implants have achieved long-term fixation, cementless components with conventional polyethylene have had survivorship limited by wear and osteolysis [22, 36]. This challenges the survivorship of THA, especially when the average lifespan of the general population has increased over the last century by 30 years. One third of 50-year-old females will live to be 100 years old . Therefore, the durability of THA must meet the demands of a population that is more active and living longer.
The introduction of highly cross-linked polyethylene (HXLP) was a major advance in THA. The chemical bond formed by ionizing radiation followed by secondary annealing has led to a measurable decrease in wear . Concerns exist, however, with reduction in the mechanical properties of the polyethylene and oxidation by free radicals. In a study by Rothman et al. , a lightly cross-linked polyethylene (ArCom (Biomet, Warsaw, IN)) was compared to a highly cross-linked polyethylene (Crossfire (Stryker Orthopaedics, Mahwah, NJ)). The volumetric wear was significantly reduced from 79.9 mm3/year in ArCom to 41.1 mm3/year in Crossfire (p = 0.0002) . These results have been duplicated in other studies [1, 3]. Calvert, et al. reported more than 100% volumetric wear reduction of HXLP vs. conventional polyethylene in a randomized prospective study . Long-term data reported by Engh et al. showed the wear rate of conventional polyethylene to be 0.23 mm3/year as opposed to 0.04 mm3/year in HXLP . The mechanical strength of a third-generation highly cross-linked polyethylene (X3, Stryker Orthopaedics, Mahwah, NJ) as measured by yield and ultimate fatigue has also been reported to be not significantly different from conventional polyethylene . Electronic spin resonance evaluation of X3 has demonstrated the virtual elimination of free radicals . Given the recently published short-comings of hard-on-hard bearing surfaces, the senior author utilizes a delta ceramic head on X3 polyethylene for patients under 70 years old and a metal head on X3 polyethylene for patients 70 years and older.
Pain control and accelerated rehabilitation are not isolated from the above discussion. A multifaceted approach to accelerated rehabilitation is employed at the Rothman Institute . Accelerated rehabilitation begins with patient selection. Patients deemed appropriate candidates for accelerated rehabilitation are those who are physiologically young, of ideal body weight, and are not on preoperative narcotic medications. The patients undergo a preoperative educational program starting with the preoperative surgical evaluation, continuing with an educational class (for patients and family), and so-called “prehabilitation” as necessary. Stable initial fixation of the hip arthroplasty components allows patients to weight-bear as tolerated immediately after surgery . Accelerated rehabilitation is also facilitated by eliminating the so-called hip precautions . Proper perioperative analgesia enables the patient to comfortably rehabilitate immediately after surgery. An extended release epidural morphine sulfate injection (DepoDur; EKR Therapeutics Inc., Bedminster, NJ), given preoperatively, provides perioperative analgesia. Furthermore, perioperative injection of marcaine, epinephrine, and ketorolac has been shown to reduce pain without significant increase in complications . The use of intravenous narcotics has been greatly reduced. A multimodal regimen of nonsteroidal anti-inflammatory medications and anti-emetics, with limited oral narcotic medications has reduced the incidence of nausea . Nasal oxygen and intravenous and bladder catheters are removed early to facilitate patient movement.
The above perioperative protocol has shown that it is possible to create a matrix of a 24-h stay after THA but the long-term safety has not been established. The impact of length of stay on mortality is unknown. Ottenbacher, et al.  demonstrated that there was a small, but consistent, increase in mortality from 1994 to 2001 as length of stay at rehabilitation centers decreased. The main concern is that serious complications such as venous thromboembolic events, myocardial infarction, and symptomatic anemia may occur in a suboptimal setting.
Total hip arthroplasty is one of the most successful interventions of modern medicine. The outcome of THA as measured by pain relief and function has been nearly optimized. The evolution of THA in recent years has focused on prolonging the durability of THA, especially as the population of patients expected to require THA expands. Perioperative pain management protocols and accelerated rehabilitation have improved the ability of patients to recover after the operation.
The ceiling effect for THA may be such that any improvements may be in the field of bioengineering. The future of total hip arthroplasty may be so-called smart implants. Smart implants may be able to reduce the incidence of infection by attaching antibiotics to the prosthesis and osteoinductive materials may improve osseointegration .
As with the evolution of any process, care must be taken to undergo vigorous scientific evaluation of any changes. This is especially true, given the near perfect pain relief and function experienced with THA. This paper has described the evolution of THA at the Rothman Institute. Each step in the evolution must be carefully evaluated in controlled trials.
The main limitation of this review is that it focuses on one institution's experience with THA. The rationale for choice of implant design, bearing surface option and rehabilitation protocol is dictated by a multitude of factors that may differ from institution to institution. This review was designed as a summary of the Rothman Institute's experience, but excellent results have been reported with other approaches and techniques as well.
In conclusion, total hip arthroplasty is perhaps the most rewarding operation in the history of medicine. Future innovation in THA should address new challenges with younger and more demanding patients, rather than change current methods that have good survivorship records. We, as surgeons, are entrusted with keeping it safe, effective, and durable for our patients.
(MSA) certifies that he has or may receive payments or benefits from a commercial entity (Zimmer) related to this work. (RHR) certifies that he has or may receive payments or benefits from a commercial entity (Stryker, Riverside) related to this work. One or more of the authors (MSA) has received research funding (DePuy). CAH certifies that he has no conflict of interest.