Mechanisms of Pain in Osteoarthritis
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- Kidd, B. HSS Jrnl (2012) 8: 26. doi:10.1007/s11420-011-9263-7
Keywordsosteoarthritis pain inflammatory mediators peripheral sensitization central sensitization
In the past, pain mechanisms in osteoarthritis (OA) have received surprisingly little attention, although this is now changing. Attempts to discriminate between OA and other rheumatologic disorders, such as rheumatoid arthritis, through verbal descriptions of pain have generally proved unsuccessful as the patterns of pain often overlap. Use-related pain in OA is common but rest pain and night pain sometimes occur, and a variety of patterns of pain are described by different patients, varying from a dull ache to sharp, stabbing pains . It seems probable that a variety of different mechanisms contribute to symptoms in this disorder and that the relative importance varies among individuals.
The presence and severity of joint pain correlate poorly with structural evidence of joint damage. Current evidence suggests that OA joint damage predisposes to pain, but that little correlation between pain severity and the extent of joint damage exists. The probable explanation of these observations lies in that fact that pain perception arises in response to a complex series of underlying neurophysiologic events involving transduction of stimuli, transmission of encoded information, and subsequent modulation of this activity at both peripheral and more central levels. In all but acute situations, the relation between tissue injury and resultant symptoms becomes less well defined and more susceptible to extraneous influences originating both within and external to the individual.
Minor injuries or damage within the joint produce short lived excitation of specialized high threshold nociceptors with brief, spatially localized pain. More severe tissue damage associated with the release of inflammatory mediators produces not only direct nociceptor excitation, but also modified response properties to subsequent stimuli (peripheral sensitization) . Under these circumstances, the response to a noxious stimulus becomes exaggerated. Alternatively, normally innocuous stimuli such as standing or walking may produce pain.
Pathophysiology of Joint Pain
Mediators of Pain in OA
Several lines of evidence point to the importance of mediators released from either synovium or bone as being important to symptoms in OA. The presence of knee pain has been shown to correlate with MRI findings of moderate or larger effusions as well as synovial thickening . Bone marrow lesions detected on MRI are more prevalent in individuals with OA who have knee pain than in those who are symptom-free . Changes in bone marrow lesions and synovitis are associated with fluctuations in knee pain in patients with knee OA, and pain resolution occurs more frequently when bone marrow lesions become smaller .
Potential peripheral targets to control OA pain currently under investigation include inflammatory mediators and their key receptors such as prostanoids, kinins, cytokines, and chemokines; sodium and calcium ion channels; and growth factors . An example of the latter is nerve growth factor (NGF), which is produced by various cell types including fibroblasts, keratinocytes, Schwann cells, and a range of immune cells. Acting via neuronal trkA receptors, NGF sensitizes articular pain fibers and changes pain thresholds . Blocking activity of NGF with a neutralizing humanized monoclonal antibody (tanezumab) has been shown to reduce OA knee pain . However, accelerated joint damage with radiographic evidence of bone necrosis resulting in knee replacement has been reported in some patients, resulting in the FDA putting clinical trials with this compound on hold. Reasons for the accelerated damage remain unclear, but the episode raises enormously important issues for the development of future analgesics for OA. One explanation given has been that the absence of joint pain led to excessive wear; however, other possibilities include a cross-reaction between tanzemab and other (vascular) receptors or an as yet unidentified trophic role for NGF in maintenance of joint homeostasis.
Psychophysical studies of patients with symptomatic OA have reported diffuse alteration of pain perception in response to various stimuli  with subjects having increased pain intensity and significantly larger referred and radiating pain areas than matched controls. Local changes to nociceptive activity are highly unlikely to account for these findings and point to the presence of enhanced central pain processing in OA. Consistent with this, studies that have combined psychophysical methods with functional brain imaging have reported increased activation in the brainstem of OA patients following punctuate stimulation compared to controls . OA pain has also shown to be associated with increased activity in areas concerned with the processing of fear and emotions and in averse conditioning, including the cingulate cortex, the thalamus, and the amygdala . This is in accord with other studies showing an important relationship between psychosocial factors and pain reporting in OA, particularly anxiety, depression, catastrophizing, coping strategies, and social isolation .
It seems likely that OA pain reflects a state of altered pain processing such that everyday stimuli are perceived as being painful. These changes arise in response to a critical interaction with particular joint, bone, and periarticular factors that may well vary among individuals. The resultant sensitization of nociceptive pathways at both peripheral and central levels is then dependent on constitutional factors unique to an individual—such as gender, age, and previous history, as well as environmental factors including culture and lifestyle.
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