, Volume 8, Issue 1, pp 26-28,
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Date: 23 Feb 2012

Mechanisms of Pain in Osteoarthritis

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Introduction

In the past, pain mechanisms in osteoarthritis (OA) have received surprisingly little attention, although this is now changing. Attempts to discriminate between OA and other rheumatologic disorders, such as rheumatoid arthritis, through verbal descriptions of pain have generally proved unsuccessful as the patterns of pain often overlap. Use-related pain in OA is common but rest pain and night pain sometimes occur, and a variety of patterns of pain are described by different patients, varying from a dull ache to sharp, stabbing pains [1]. It seems probable that a variety of different mechanisms contribute to symptoms in this disorder and that the relative importance varies among individuals.

The presence and severity of joint pain correlate poorly with structural evidence of joint damage. Current evidence suggests that OA joint damage predisposes to pain, but that little correlation between pain severity and the extent of joint damage exists. The probable explanation of these ...