, Volume 8, Issue 1, pp 59-61
Date: 24 Jan 2012

Stem Cells in Osteoarthritis

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Introduction

Articular cartilage has significant limitations for repair or regeneration. It does not respond to an injury or disease with the normal inflammatory sequence of events that results in repair of most other tissues. The issues that preclude a functional repair in articular cartilage include its avascularity, the presence of cells (chondrocytes) that have a limited capacity to respond, and a complex structure that is difficult to reproduce. A plethora of approaches has been applied in an attempt to repair articular cartilage. Although short-term functional repair has been reported, a long-term biological regeneration has yet to be accomplished.

Cells and Cartilage Regeneration

Our laboratory has focused for the last two decades on cells as the central driver for functional long-term regeneration. The potential cells that could be used for cartilage regeneration are autologous or allogeneic chondrocytes and osteochondral progenitor cells defined as mesenchymal stem cells (MSCs).