, Volume 8, Issue 1, pp 57-58
Date: 14 Feb 2012

Tissue Engineering Strategies for Skeletal Repair

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Introduction

There is a strong medical need for biological tissue grafts that could reestablish the structure and function of skeletal tissues lost to congenital abnormalities, trauma, and disease. Both the prosthetic devices and autologous tissue grafts are most helpful in providing the necessary tissue structure, but they each have serious limitations [1]. Tissue engineering offers potential to grow fully biological substitutes of native tissues, through the individual and combined use of cells, biomaterial scaffolds, and culture systems [25].

The Potential of Bioengineered Human Tissues

In its most complex incarnation, tissue engineering involves the in vitro generation of living, functional tissue grafts by cultivation of cells on biomaterial scaffolds (designed to serve as a template for tissue formation) in bioreactors (providing environmental control and physical signaling). The design of tissue engineering systems has been guided by biological principles and the need to provide n