, Volume 8, Issue 1, pp 2-3
Date: 04 Feb 2012

Frontiers in Osteoarthritis: Executive Summary of the Scientific Meeting

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Osteoarthritis (OA) is the most common form of arthritis and represents the leading cause of disability in the USA. Importantly, with an aging population, the prevalence, impact, and economic consequences of OA will rise dramatically within the next decades. Although much has been learned concerning the factors that play a role in the initiation and progression of OA, this information has not been effectively translated into individual or public health strategies that have significantly altered the natural history of this disabling form of arthritis. While total joint arthroplasty is an effective treatment for the late stages of OA, no validated pharmacologic interventions exist for effectively eliminating pain and restoring function during disease progression.

Although initially regarded as a disease of articular cartilage, numerous lines of investigation have established that OA represents an example of total “organ failure,” in which every component of the joint tissues, including th